Objective: To rationally design new inhibitors of HIV-1 integrase.
目的：合理设计新的HIV-1整合酶抑制剂。
Because of the special function of HIV-1 integrase, it has become one of focuses of anti-AIDS drug design.
由于HIV - 1整合酶的特殊功能，它已成为抗艾滋病药物设计工作的焦点之一。
HIV-1 integrase (in) integrates viral DNA into host cells through two steps metal ions-dependent reactions.
HIV - 1整合酶(IN)通过依赖金属离子的两步反应将病毒DNA整合入宿主细胞中。
Aim To synthesize a series of new caffeic acid derivatives and test their HIV-1 integrase inhibitory activities.
目的合成新型咖啡酸衍生物并测定其抑制HIV 1整合酶活性。
Results:After being identified by PCR, restriction enzyme digestion and sequencing, the adeno-integrase hybrid system was successfully constructed.
结果：经PCR，酶切及测序方法鉴定，该腺病毒-整合酶嵌合系统构建成功。
Results Positive rates of class 1 integrase gene was 61.4%(113/184) in clinical isolates, class 2 integrase gene 4.3%(8/184) and class 3 integrase gene zero.
结果1类整合酶基因总阳性率为61.4%（113/184），2类整合酶基因总阳性率为4.3%（8/184），未检出3类整合酶基因阳性菌株。
Inhibition experiment was performed as integrase activity assay expect that increasing concentrations of synthetic peptides were preincubated with the integrase.
实验方法与整合酶活性检测相似，只是整合酶需要和合成的多肽先进行预反应。
The application value of each representative system was evaluated to provide some guidance for the platform established for the drug design and screening of HIV-1 integrase inhibitors.
给出了各个代表性体系的应用价值。旨在对HIV - 1整合酶抑制剂药物设计及筛选平台的建立提供一定的参考。
The application value of each representative system was evaluated to provide some guidance for the platform established for the drug design and screening of HIV-1 integrase inhibitors.
给出了各个代表性体系的应用价值。旨在对HIV - 1整合酶抑制剂药物设计及筛选平台的建立提供一定的参考。
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