Prolonged activation of the insulin receptor, inflammation, and excessive insulin levels can induce insulin resistance by decreasing levels of insulin receptor substrate (IRS) proteins.
通过减少胰岛素受体底物（IRS）蛋白的水平能够增加胰岛素受体活性时间、炎症时间和胰岛素水平，从而有助于降低胰岛素抵抗程度。
The variant, designated IVS5-13insC, impairs function of the HMGA1 protein, a cofactor for gene activation that regulates insulin-receptor gene (INSR) expression.
这个变异称为IVS5-13insC，造成HMGA1蛋白的功能损伤，HMGA1蛋白是调节胰岛素受体基因（INSR）表达的辅助因子。
The variant, designated IVS5-13insC, impairs function of the HMGA1 protein, a cofactor for gene activation that regulates insulin-receptor gene (INSR) expression.
这个变异称为IVS5-13insC，造成HMGA1蛋白的功能损伤，HMGA1蛋白是调节胰岛素受体基因（INSR）表达的辅助因子。
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