Time for Testing Incretin Therapies in Early Type 1 Diabetes?
早期1型糖尿病中测试肠促胰岛素疗法的时间？
Incretin mimetics are a new class of treatment in the fight against diabetes.
模拟分泌物是抗糖尿病的一类新的治疗。
Beyond that it becomes less clear; the modulators of incretin axis appear to be promising.
除此以外的结果不够明确。肠促胰岛素调节剂变得很有希望。
What is pretty clear is that the contribution of GIP, the other incretin hormone, is modest.
非常清楚的是，GIP(另一种肠促胰岛素)的贡献不大。
What makes it different is that it is based on the incretin hormone, GLP-1, which is secreted after a meal.
与众不同之处在于这类药物的作用机制是基于肠促胰岛素GLP-1的，GLP-1是在餐后分泌的。
First of all generally speaking incretin related drugs are more effective for Japanese compared to Caucasians.
首先，总体来讲，肠促胰素相关药物对日本人的疗效优于白人。
Internation Diabetes: And now it's very trended to discuss about incretin , have you ever tried to use incretin ?
李文慧博士：目前肠促胰岛素是大家讨论的热点问题，您是否应用过？
Prof Bloomgarden: Another effect of the incretin-based therapies would simply be to allow patients to not use sulfonylureas.
肠促胰岛素相关治疗的另一个作用简单地说就是可以使患者不使用磺脲类药物。
The incretin effect was measured as the difference in insulin levels in response to oral and to an isoglycemic iv glucose load.
用肠促胰岛素的效应来检测口服葡萄糖和同等血糖静脉葡萄糖负荷后胰岛素水平的不同。
In fact gastric emptying does not occur with incretin therapy where as it does occur with GLP 1 analog therapy used at pharmacologic levels.
事实上，肠促胰岛素治疗不会发生胃排空，而GLP -1的类似物在治疗水平就会发生胃排空。
What we need to determine is actually how much of the reduced incretin effect is a consequence of the diabetes rather than a cause of the diabetes.
我们需要去证实的是肠促胰岛素的作用下降对糖尿病的作用有多大，而并非它就是糖尿病的病因。
We ourselves have done a study that should give such results but the incretin levels haven't been measured yet so the overall results are still pending.
我们自己已经进行的一项研究将给出这样的结果，但研究没有进行肠促胰岛素水平测定，因此最终的结论仍是悬而未决。
OBJECTIVE We evaluated whether a whey preload could slow gastric emptying, stimulate incretin hormones, and attenuate postprandial glycemia in type 2 diabetes.
目的：评价餐前进食乳清是否可以延缓胃排空、促进肠激素的分泌以及降低2型糖尿病患者的餐后高血糖。
The medicine blocks the degradation of incretin hormones that are released in the digestive tact in response to food, and mediate glucose-dependent insulin secretion.
药物阻止在消化食物中释放的肠降血糖素的降解，调节血糖依赖胰岛素的分泌。
I think the current feeling is that the impaired incretin response is a secondary consequence not pathogenesis of diabetes, although it may be a small distributing factor.
我认为当前的观点是肠促胰素应答受损是糖尿病的次级后果，而非糖尿病的病因，尽管它可能是一个小的致病因素。
Objective: to determine whether the magnitude of the change of the incretin levels and effect is greater after GBP compared to a low caloric diet, after equivalent weight loss.
研究目标：此项研究的目的是确定达到同样的减肥效果胃旁路手术所致肠促胰岛素水平的变化以及影响与低热量饮食相比是否更显著。
Conclusions: These data suggest that early after GBP, the greater GLP-1 and GIP release and improvement of incretin effect are related not to weight loss but rather to the surgical procedure.
研究结论：这些数据显示胃旁路手术早期胰高血糖素样肽- 1和胰高血糖素的大量释放以及肠促胰岛素效应的增加和体重减轻没有关系而是和手术操作有关。
Conclusions: These data suggest that early after GBP, the greater GLP-1 and GIP release and improvement of incretin effect are related not to weight loss but rather to the surgical procedure.
研究结论：这些数据显示胃旁路手术早期胰高血糖素样肽- 1和胰高血糖素的大量释放以及肠促胰岛素效应的增加和体重减轻没有关系而是和手术操作有关。
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