Conclusion: a low cost, high yield, and simple process for preparation of sodium ibandronate is provided.
结论：本方法提高了反应收率，降低了成本，简化了操作，是合成伊班膦酸钠的有效途径之一。
Objective To study the curative effect of ibandronate combined with chemotherapy in the treatment of metastatic bone cancer.
目的探讨伊班膦酸钠（艾本）联合化疗治疗骨转移癌的临床疗效。
Conclusion: Ibandronate can effectively relieve bone pain caused by Multiple Myeloma and drop serum calcium, to treat hypercalcemia.
结论：伊班膦酸钠能有效缓解多发性骨髓瘤患者骨痛，降低血钙，治疗高钙血症。
AIM: to evaluate the efficacy of Ibandronate in relieving bone pain and the tolerability in malignant tumor patients with bone metastases.
目的：评价伊班磷酸钠治疗恶性肿瘤骨转移引起的骨痛及其不良反应。
Objective To evaluate therapeutic effect and adverse effect of ibandronate combined with chemotherapy in breast cancer patients with bone metastases.
目的观察伊班膦酸钠(艾本)联合化疗对乳腺癌骨转移的止痛效果和不良反应。
METHODS: All 68 patients were treated with ibandronate during the intermission of chemotherapy. Bone pain, ADL, bone metastasis focus, change of serum Ca2 + level and side effect were observed.
方法：在化疗间歇期应用伊班膦酸钠治疗骨转移癌患者68例，观察骨痛、活动能力、骨转移病灶、血钙变化及不良反应。
METHODS: All 68 patients were treated with ibandronate during the intermission of chemotherapy. Bone pain, ADL, bone metastasis focus, change of serum Ca2 + level and side effect were observed.
方法：在化疗间歇期应用伊班膦酸钠治疗骨转移癌患者68例，观察骨痛、活动能力、骨转移病灶、血钙变化及不良反应。
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