In the radiation dose range used, the colony efficiency of the lymphocytes was negatively correlated to the radiation dose, while the HPRT mutation frequency is positively correlated.
在一定剂量范围内，人外周血淋巴细胞克隆效率与照射剂量呈负相关，HPRT基因突变频率与照射剂量呈正相关。
Objective To explore the possibility of HPRT locus mutation in peripheral blood lymphocytes as a biomarker for screening those tumor susceptible people.
目的探讨外周血淋巴细胞HPRT基因突变作为筛选肿瘤高危人群的一个生物学标志的可能性。
The HPRT gene mutation frequencies had better linear relations with chromosome aberrations and micronuclei.
HPRT基因突变频率与染色体畸变、微核具有良好的相关性。
Objective to study HPRT gene mutation in rat peripheral blood lymphocytes induced by internal exposure to radionuclides using cloning method.
目的用克隆法研究放射性核素内照射诱发的大鼠外周血淋巴细胞HPRT基因突变情况。
Methods A simple, rapid and sensitive poly-nuclear cell assay was used to investigate the frequency of HPRT locus mutation.
方法采用多核细胞法研究肿瘤患者外周血淋巴细胞HPRT基因位点的突变频率，并与正常人群进行对比。
Methods HPRT gene mutation frequency was examined by the technique of multinuclear cell assay.
应用多核细胞法检测外周血淋巴细胞HPRT基因突变率。
Methods HPRT gene mutation frequency was examined by the technique of multinuclear cell assay.
应用多核细胞法检测外周血淋巴细胞HPRT基因突变率。
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