Researchers in Osaka are developing a drug to mimic HMGB1.
大阪的研究人员正在开发一种模拟HMGB1的药物。
AIM: to screen the binding proteins to HMGB1 promoter by phage display technique.
目的：筛选高迁移率族蛋白b 1 (HMGB1)启动子结合蛋白。
Conclusion: TAP can directly induce the release of HMGB1 of pancreatic acini cell.
结论：TAP可直接诱导胰腺腺泡细胞内hmgb1的释放。
He envisaged treatments in which a drug similar to HMGB1 would be injected near to a wound.
他设想了一些治疗方法，可以将一种类似于HMGB1的药物注射到伤口附近。
HMGB1 may play an important role as a modulator in apoptotic changes in PMN during LPS-induced ALI.
HMGB1在脂多糖诱导的急性肺损伤(ALI)P MN凋亡改变中有重要的调节作用。
Can the HMGB1-CD24-Siglec system limit the more severe forms of sterile inflammation, such as sepsis?
HMGB1 -CD 24 -Siglec系统能限制更严重的无菌性炎症反应，如脓毒症吗？
Recent studies have suggested that HMGB1 might be a potential "late" inflammatory mediator in sepsis.
新近研究表明，HMGB1可能是一种重要的晚期炎症介质。
Recently, the traditional DNA-binding protein HMGB1 was discovered as a potent proinflammatory cytokine.
近年来发现高迁移率族蛋白B1（HMGB1）这一传统DNA结合蛋白是强大的致炎细胞因子。
This treatment causes the release of HMGB1, and thus leads to inflammation in the absence of any pathogen.
这种处理导致HMGB1的释放，因此在无任何病原体的情况下产生了炎症反应。
HMGB1 plays roles in activation of plasminogen and matrix metalloproteases, reorganization of cytoskeleton.
HMGB1与纤维蛋白酶原、基质金属蛋白酶的活化、细胞骨架重组等有关。
Objective To construct the recombinant vector, the expression of human HMGB1 code gene and to study its function.
目的构建人高迁移率族蛋白1（HMGB1）编码基因的表达载体，获得纯化的重组蛋白，研究其生物学功能。
In addition, the intracellular localization of HMGB1 in the monocytes was investigated by immunocytochemical analysis.
另采用细胞免疫荧光法观察培养的外周血单核细胞中HMGB1的胞内定位。
Objective To prepare monoclonal antibody specific for HMGB1 and establish a direct competitive ELISA for assaying serum HMGB1.
目的制备高迁移率族蛋白b 1 (HMGB1)单克隆抗体和建立HMGB1的直接竞争ELISA测定方法。
AIM: To investigate the translocation of high-mobility group box 1 protein (HMGB1) in THP-1 cells induced by mechanical stretch.
目的：探讨机械牵张对高迁移率族蛋白b1 (HMGB1)在THP - 1细胞内移位的影响。
Objective: to investigate whether high mobility group box chromosomal protein 1 (HMGB1) can activate macrophages to secrete IL-18.
目的：探讨高迁移率族蛋白1 (HMGB1)能否激活巨噬细胞表达IL - 18及其受体。
And the plasma level of HMGB1 obviously elevated in both group 24 hour after the endotoxin injection, then started to drop slowly.
HMGB1蛋白水平于内毒素注射后1 h无明显升高，至24 h两组均显著升高，后呈缓慢下降趋势。
Objective To observe the localization and translocation of human high mobility group protein B1 (HMGB1) protein in eukaryotic cells.
目的观察人高迁移率族蛋白b 1 (HMGB1)在真核细胞内的定位和移位情况。
Objective: High mobility group box 1 protein (HMGB1) as a late-acting cytokine mediates lethality of sepsis and systemic inflammation.
目的：高迁移率族蛋白b1 (HMGB1)作为一种晚期炎症介质，介导了脓毒症和其他系统性炎症的致死性效应。
In fact, HMGB1 was found to directly associate with CD24 and Siglec-G, a member of the sialic acid-binding immunoglobulin-like lectin family.
实际上，HMGB1被发现与CD 24和Siglec - g，唾液酸结合性免疫球蛋白样凝集素家族中的一员直接相关。
AIM: To observe the mechanism that rapamycin (RPM) affects HMGB1 expression and release in RAW264.7 cells induced by lipopolysaccharides (LPS).
目的：探讨雷帕霉素抑制LPS诱导小鼠raw264.7细胞表达和释放HMGB1的作用机制。
Objective to investigate the potential receptor for high mobility group box-1 protein (HMGB1) on immune function of peritoneal macrophages in mice.
目的探讨高迁移率族蛋白b 1 (HMGB1)对巨噬细胞免疫功能影响的可能受体机制。
Xuebijing could attenuate the degree of acute lung injury in rats induced by LPS, which may be related to its inhibition of the HMGB1 protein expression in lung tissue.
结论血必净可明显抑制脂多糖诱导的急性肺损伤大鼠肺组织增强的HMGB1表达，减轻脂多糖诱导的大鼠肺损伤程度。
Objective to investigate the effects of high mobility group box-1 protein (HMGB1) on surface receptor expression of splenic dendritic cells (DCs) and its potential mechanism in rats.
目的观察高迁移率族蛋白b 1 (HMGB1)对大鼠脾脏树突细胞(DC)作用的受体机制。
ABSTRACT: Objective to investigate the significance of changes in plasma high mobility group box-1 protein (HMGB1) levels and its relationship with sepsis and endotoxemia in severely burned patients.
摘要：目的动态观察严重烧伤患者血浆中高迁移率族蛋白b 1 (HMGB1)水平的变化并探讨其与脓毒症及内毒素血症的关系。
ABSTRACT: Objective to investigate the significance of changes in plasma high mobility group box-1 protein (HMGB1) levels and its relationship with sepsis and endotoxemia in severely burned patients.
摘要：目的动态观察严重烧伤患者血浆中高迁移率族蛋白b 1 (HMGB1)水平的变化并探讨其与脓毒症及内毒素血症的关系。
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