This article mainly reviews the features of SAN pace-making gene HCN4 in relation to SAN function.
现就窦房结细胞起搏基因hcn4的特性及其与窦房结功能之间的关系作进一步研究和探讨。
Recent studies show that human SAN pace-making gene HCN4 mutations are closely associated with sick sinus syndrome.
近年来有较多研究表明，人窦房结起搏基因HCN4突变与病态窦房结综合征密切相关。
Results Immuno-fluorescent staining presented the discontinuous punctiform or linear expression of HCN2 in cardiomyocytes membrane, but not for HCN4.
结果免疫荧光结果显示HCN2在心室肌细胞膜上呈点状或短线状不连续表达；HCN4未见表达。
Recently, a family of hyperpolarization-activated and cyclic nucleotide-gated cation(HCN) channels comprising at least four members (HCN1-HCN4) has been cloned.
新近，一类被命名为超极化激活及环化核苷酸调控的阳离子（HCN）通道被克隆。
Therefore the other aim of our study is to discover SNPs of HCN4 exon 1, including the regulatory sequence and exon-intron boundary of it, which plays an importable role of channel function.
因此选择对基因的表达具有重要功能的外显子1和其上游的调控区及下游外显子内含子交界区序列通过直接测序法进行SNP筛查，并进一步分析多态位点与病窦的关联性。
Therefore the other aim of our study is to discover SNPs of HCN4 exon 1, including the regulatory sequence and exon-intron boundary of it, which plays an importable role of channel function.
因此选择对基因的表达具有重要功能的外显子1和其上游的调控区及下游外显子内含子交界区序列通过直接测序法进行SNP筛查，并进一步分析多态位点与病窦的关联性。
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