The development of tumor results from complex action among multiple factors such as oncogene activation, anti-oncogene inactivation, disturbance of apoptosis related gene and so on.
肿瘤的发生是原癌基因激活、抑癌基因失活以及凋亡相关基因失调等诸多因素综合作用的结果。
It has been proved that the occurrence of oncogenesis is in close relationship with the oncogene activation, the tumor suppressor gene inactivation and the disorder of cell cycle modulation.
目前在分子水平上的研究显示肿瘤的发生与癌基因的激活和抑癌基因的失活以及细胞周期调节失控密切相关。
Study on the mechanisms of 'escape' is helpful to the understanding of gene regulation by X inactivation.
探讨这些基因逃避X失活的机制有助于理解X染色体失活是如何对基因表达进行调控的。
DNA methylation may be an important mechanism of inactivation of RUNX3 gene in HCC.
甲基化机制可能是肝细胞癌runx3基因失活的重要机制之一。
The methylation of histone H3-K27 was proved to be linked to several silencing phenomena including homeotic-gene silencing, X inactivation and genomic imprinting.
组蛋白H3第27位赖氨酸的甲基化与同源盒基因沉默、X染色体失活、基因印记等基因沉默现象有关；
This phenomenon is mostly seen in imprinted genes and X-chromosome inactivation where DNA methylation of promoter regions leads to repression of gene expression.
这种现象主要在印迹基因和X染色体失活区域看到，这些区域中的启动子区的DNA甲基化导致了基因表达的抑制。
The different mechanisms, such as the activation of oncogenes, the inactivation and mutation of tumor suppressor gene, antiapoptosis and so on are involved in .
原癌基因的激活，抑癌基因的失活、突变，抗细胞凋亡等不同的机制都可能参与其中。
Conclusion the inactivation of er gene has a close relationship with the abnormal methylation of er gene promoter.
结论人乳腺癌er基因的失活与其基因启动子高甲基化关系密切。
BRCA-1-associated protein (BAP1) is a tumor suppressor gene, which shows biallelic inactivation in approximately half of all mesotheliomas.
BRCA - 1相关蛋白(BAP1)是一种肿瘤抑制基因，约半数的间皮瘤中显示双等位基因失活。
Objective To explore the relationship between X - linked spondyloepiphyseal dysplasia tarda (SEDL) gene escaping X chromosome inactivation( XCI) and SEDL phenotype.
目的探讨X-连锁迟发性脊椎骨骺发育不良（SEDL）基因逃避X染色体失活（XCI）及与临床表型的关系。
The inactivation of MGMT gene may urge the proto oncogene activation.
MGMT基因的失活常导致原癌基因的激活。
Various chemical inducible systems based on activation and inactivation of the target gene had been described.
建立于目标基因激活和失活基础之上的几个化学分子诱导基因表达系统已有报道。
There may exist a mechanism at gene translation level which leads to the inactivation of the p16 and Rb genes.
在翻译水平上也存在着引起基因失活的可能机制。
Recent studies showed that ARF gene may play a role in tumorigenesis; the ARF gene promoter hypermethylation may be the principal mechanism in the inactivation of this gene.
目前研究表明ARF基因在肿瘤发生过程中可有起一定的作用，ARF基因功能的失活可能主要通过该基因启动子高度甲基化。
The study shows that the inactivation of gene Atp6v0d2 in mice results in dramatically increased bone mass due to defective osteoclasts as well as enhanced bone formation.
研究表明，小鼠Atp6v0d2基因的失活，导致骨量显著增加，其主要原因为破骨细胞功能缺失和骨形成增加。
Objective to study the clonality of palmar fibromatosis by molecular genetic analysis of X chromosome inactivation pattern at a polymorphic site of human androgen receptor gene (HUMARA).
目的通过人雄激素受体(HUMARA)基因位点克隆性分析技术确定掌纤维瘤病是否为肿瘤性增生。
Biallelic inactivation of the NF2 gene was detected in 36% of meningiomas.
NF 2双等位基因钝化可在36%的脑膜瘤中检测到。
Biallelic inactivation of the NF2 gene was detected in 36% of meningiomas.
NF 2双等位基因钝化可在36%的脑膜瘤中检测到。
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