This study was to explore the clinical significance of FLT3 internal tandem duplication (FLT3/ITD) in acute myeloid leukemia (AML) with chromosome abnormality.

本研究旨在探讨伴有染色体异常急性髓系白血病患者FLT3跨膜区内部串联重复突变检测的临床意义。

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Using genomic PCR and sequencing, FLT3/ITD mutation with or without chromosome translocation were examined in AML patients.

采用PCR联合序列检测伴有或不伴有染色体易位的急性髓性白血病患者FLT3基因突变情况。

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FLT3 Internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations are seen in 30% of AML patients (PTS) and are associated with poor survival.

30%的急性髓系白血病(aml)患者发生FLT3内部串联重复(itd)和酪氨酸激酶域(TKD)突变，而且生存预后较差。

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FLT3 Internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations are seen in 30% of AML patients (PTS) and are associated with poor survival.

30%的急性髓系白血病(aml)患者发生FLT3内部串联重复(itd)和酪氨酸激酶域(TKD)突变，而且生存预后较差。

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