The microhardness increases first and then remains at a certain level with the increasing passes, while the route effects on hardness are related to the pass number and the refinement effects.
随挤压次数增加，硬度先增大后保持基本不变，而挤压路径对硬度的影响与挤压次数、挤压后细化效果密切相关。
For drugs with an active metabolite, the therapeutic consequence of first-pass metabolism depends on the contributions of the drug and the metabolite to the desired and undesired effects.
对于那些生成活性代谢物的药物来讲，经过首过代谢的治疗上的重要性取决于药物和代谢物所引起的期望的和非期望的效应。
For drugs with an active metabolite, the therapeutic consequence of first-pass metabolism depends on the contributions of the drug and the metabolite to the desired and undesired effects.
对于那些生成活性代谢物的药物来讲，经过首过代谢的治疗上的重要性取决于药物和代谢物所引起的期望的和非期望的效应。
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