Exosome can deliver tumor-derived antigens to induce anti-tumor immune responses.
外泌体可提供肿瘤来源的抗原来诱导抗肿瘤的免疫反应。
We have already discussed the role of exosome in cancer therapy when answering the previous question.
在回答前一个问题时,我们已经讨论了外泌体在癌症治疗中的作用。
However, the more important role of exosome seems to be modulation of microenvironment by paracrine mechanisms.
然而,外泌体更重要的作用似乎是通过旁分泌机制调控微环境。
Exosomes could target specific cell types or tissues so exosome delivery may improve efficacy and reduce off-target effects.
外泌体可以靶向特定的细胞类型或组织,这样的外泌体输送可能会提高疗效,减少脱靶效应。
Therefore, we should thoroughly understand the complexity of exosome biology before widely implementing exosomes in clinical trials.
因此,在临床试验中广泛推行外泌体之前,我们应当彻底了解外泌体的生物复杂性。
Thirdly, considering cancer-cell derived exosome can modify pre-metastasis niches [6], depleting these exosomes from circulation system is a possible option for blocking cancer metastasis.
第三,由于肿瘤细胞来源的外泌体可修饰转移前微环境境[6],从循环系统中去除这些外泌体可能可以阻止癌症的转移。
Taken together, these results suggest that FFC and the exosome are part of a posttranscriptional negative feedback loop that regulates frq transcript levels and the circadian output pathway.
这些实验表明,FFC和外核体是组成转录后负调控反馈环路的组成部分。
Although exosome biomarkers for diagnosis or prognosis seem to be on the fast track for translational application, both cancer diagnosis and therapy based by exosomes have bright perspectives.
虽然外泌体作为生物标志物用于诊断或预后在转化应用上推进很快,但基于外泌体的癌症诊断和治疗两方面都有很好的前景。
Although exosome biomarkers for diagnosis or prognosis seem to be on the fast track for translational application, both cancer diagnosis and therapy based by exosomes have bright perspectives.
虽然外泌体作为生物标志物用于诊断或预后在转化应用上推进很快,但基于外泌体的癌症诊断和治疗两方面都有很好的前景。
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