Bioavailability determinations based on the peak plasma concentration can be misleading, because drug elimination begins as soon as the drug enters the bloodstream.
单靠峰时血浆浓度来确定生物利用度会导致误解，因为药物一进入血流就会开始药物消除。
Renal clearance is used to determine renal elimination mechanisms of a drug, which is the result of glomerular filtration, active tubular secretion and reabsorption.
肾清除率常用来表示药物在肾中的排除机制，它是肾小球滤过和肾小管分泌与重吸收的作用结果。
Drug delivery through the nasal route has received a lot of attention recently because of its advantages such as rapid absorption, avoidance of first-pass elimination and so on.
鼻腔给药具有吸收迅速、避免首过代谢等优点，在近年来已引起广泛关注。
Drug delivery through the nasal route has received a lot of attention recently because of its advantages such as rapid absorption, avoidance of first-pass elimination and so on.
鼻腔给药具有吸收迅速、避免首过代谢等优点，在近年来已引起广泛关注。
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