The regulation of UGT1A1 and UGT2B1 by dexamethasone was dose and time dependent.
地塞米松对UGT1A1和UGT2B1表达的调节作用具有时间及剂量依赖效应。
RESULTS Both DDP and VP16 obviously inhibited the lung cancer cell growth with dose and time dependent.
结果不同浓度VP16和DDP对肺癌细胞生长均有明显的抑制作用，并有浓度和时间的依赖性。
RESULTS the inhibiting effect of TG on the islet cells growth by TG was in a dose and time dependent manner.
结果TG对细胞生长呈浓度及时间依赖性抑制作用。
RESULTS SODN inhibited the growth of CNE1 and CNE2Z cells as well as ASODN, and presented dose and time dependent manner.
结果端粒酶正义寡核苷酸与反义寡核苷酸一样可抑制鼻咽癌cne1和CNE2 Z细胞的生长，且呈剂量和时间依赖性。
Conclusion PTS can inhibit the RPE proliferation possibly by inhibiting DNA synthesis and intervening RPE metabolism. The effect was dose and time dependent.
结论PTS可能通过抑制DNA合成、干扰rpe细胞代谢对RPE细胞增殖具有剂量依赖和时间依赖方式的抑制作用。
Microcystins can interfere with the development of embryos, delay hatching time, reduce hatchability and increase malformation rate with a dose-dependent manner.
微囊藻毒素能干扰鱼类胚胎发育，延迟出膜时间，降低孵化率，增加畸形率，而且还具有剂量依赖效应。
Conclusion progesterone was involved directly in osteocalcin production by regulating gene expression and this effect of progesterone was time and dose dependent.
结论孕酮从基因水平调节离体胎鼠成骨细胞骨钙素的生成，这种调节呈现时间及剂量依赖。
ATRA could induce morphological differentiation and inhibit growth of SY5Y cells and showed time and dose dependent manner.
ATRA对SY5Y细胞有抗增殖作用和诱导细胞分化作用，并呈一定时间和剂量依赖关系。
The effect of the hormone was time and dose-dependent.
激素的作用呈时间及剂量依赖性。
Results Venenum Bufonis had growth inhibitory and apoptosis-inducing effects on U2OS cell with a time and dose dependent relation.
结果蟾酥水提取物对U2 OS细胞具有生长抑制及诱导凋亡作用，且呈时间依赖和剂量依赖。
Conclusion: 2, 5-hd inhibited the survival, induced apoptosis and injury of PC12 cells in a dose - and time-dependent manner.
结论：2,5- HD呈剂量和时间依赖性抑制PC 12细胞存活和增殖，诱导细损伤和凋亡。
All the effects were in a time and dose dependent manner.
上述作用均呈时间和剂量依赖性。
CONCLUSION: CsA can inhibit hypertensive cardiac hypertrophy, but large dose or longer period of application will lead to severe myocardial edema, which is dose-dependent and time-dependent.
结论：环孢霉素A可抑制高血压心肌肥大，但较大剂量或较长时间应用则会产生严重心肌水肿，并且这种作用是剂量、时间依赖性的。
Results IL 6 up regulated the expression of CD14 and down regulated the expression of SR in a time and dose dependent fashion at the level of mRNA.
结果在基因转录水平，IL6对CD14表达呈时间剂量依赖性上调，对SR的表达呈进行性下调；
The percentage of apoptotic cells was a time- and dose- dependent manner.
流式细胞仪检测出凋亡细胞百分率呈时间剂量依赖关系；
Curcumin significantly inhibited HSC proliferation and induced apoptosis in dose and time-dependent manner.
姜黄素可以抑制HSC增殖，诱导其发生凋亡，具有剂量和时间依赖性。
Results: Paclitaxel inhibited the growth of A375 cells by inducing apoptosis in a both time-dependent and dose-dependent manner(P<0.01).
结果：紫杉醇通过诱导细胞凋亡抑制A375细胞生长，并呈时间和剂量依赖性（P<0.01）；
Results Resveratrol inhibited the proliferation of RPMI-8226 and KM3 cells in a time-and dose-dependent manner.
结果白藜芦醇对RPMI- 8226和KM 3细胞具有明显的增殖抑制作用，其抑制增殖作用呈时效和量效关系。
Conclusion Matrine could inhibit the proliferation of PC-3 cells in dose - and time-dependent manners in vitro.
结论苦参碱在体外可抑制PC- 3细胞的增殖，具有时间和浓度依赖关系。
Results Triptergium Wolfordii obviously inhibit the cell proliferation and the secretion of hyaluronic acid of the human orbital fibroblast in vitro, and it was in a time-and dose-dependent manner.
结果雷公藤多甙可明显抑制正常人眼眶成纤维细胞的增殖和透明质酸的分泌，并呈剂量和时间依赖性抑制。
Results Dasatinib markedly inhibited the proliferation of B16F10 cells in a dose-and time-dependent manner.
结果达沙替尼对B16 F 10细胞的增殖有抑制作用，并呈浓度和时间依赖性。
Result : MTT assay showed that sinensetin inhibited the growth of AGS gastric cancer cells in a dose- and time-dependent manner.
结果 ：甜橙黄酮可明显抑制AGS胃癌细胞的增殖，呈时间和剂量依赖性；
After exposed to P. lima, the level of DSP toxins in the gill of Perna viridis increased significantly in a dose-dependent relationship with time, and achieved the highest at the 3rd day.
毒素积累阶段，翡翠贻贝鳃组织中DSP毒素显著增加，于第3 d时达到最高，呈明显的剂量和时间依赖关系。
ResultsThe growth of CNE-2 cells was significantly inhibited by Oxaliplatin in a dose-dependent and time-dependent fashion.
结果奥沙利铂对CNE - 2细胞的生长抑制率随药物浓度和作用时间的增加而增大。
Conclusion Sunitinib inhibited bladder cell line T24 proliferation in dose-dependent and time dependent manner.
结论苹果酸舒尼替尼可呈浓度和时间依赖地抑制膀胱癌t 24细胞系增殖。
Conclusions: Sunitinib inhibited bladder cell line T24 proliferation in dose-dependent and time dependent manner.
结论：苹果酸舒尼替尼可呈浓度和时间依赖地抑制膀胱癌t 24细胞系增殖。
Results The proliferation of MG-63 cells was significantly inhibited by GAA in a dose-dependent and time-dependent manner.
结果GAA对MG-63细胞具有显著的增殖抑制作用，并呈剂量、时间依赖性；
Conclusions Metformin can inhibit the growth of lung adenocarcinoma cell lines significantly and potentiate cisplatin in a dose - and time-dependent manner in vitro.
二甲双胍与顺铂共同作用可以增强对肺腺癌细胞生长的抑制作用。
The results showed that deguelin inhibited the proliferation of K562 cells in a time- and dose-dependent manner;
结果表明：鱼藤素能显著抑制K562细胞的增殖，并与作用时间和鱼藤素浓度呈依赖关系；
Results LPS activated complement in a dose-and time-dependent manner.
结果LPS能够激活血清补体，这种激活呈现量效、时效性。
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