The abnormal DNA modification is characteristically a hallmark of cancer cells.
不正常的DNA修饰是癌症细胞的典型特征。
This platform provides a homogeneous DNA assay that takes advantage of the fluorescence detection method, but with minimal DNA modification.
在对DNA进行最小修饰的前提下，此平台借助于荧光探测的方法提供了一个均质的DNA分析技术。
His research work at Harvard led to the discovery of a family of DNA modification enzymes that establish DNA methylation patterns of the human genome.
沿着他在哈佛的科研方向，后人发现了一族DNA修饰酶，这些酶能使人类染色体呈现多种甲基型态。
DNA modification with restriction-modification system is a component of microbial immune system, and DNA modification without restriction system influences phenotypes by gene regulation.
由限制-修饰系统调控的DNA修饰参与微生物的免疫防御系统，无限制-修饰系统调控的DNA修饰通过调控基因表达影响表型。
UCLA researchers also compared the neural stem cells they grew to cancer cells to ensure that the neural stem cells did not have any abnormalities in a DNA modification associated with gene silencing.
UCLA的研究人员同时也比较了他们的干细胞和癌症细胞的DNA以保证这些神经干细胞没有导致基因沉默的不正常的DNA修饰。
Methylation is an epigenetic modification to one's DNA that changes a gene's activity, generally reducing that activity within the genome.
甲基化作用是对DNA的后天修改，并改变基因活动，通常是在基因组内减少这个活动。
Genetic modification can be used to cut out selected pieces of DNA (or genes) using special enzymes.
基因改造，就是借助某种特别的酶，删除选中基因片段。
DNA hypomethylation, likely to be cooperating with aberrant histone modification, may induce the activation of some t cell genes and development of autoimmunity in SLE.
DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化，导致狼疮自身免疫的发生。
This modification is either the addition of methyl groups to the DNA or of acetyl groups to the histones.
这种改性或者是甲基增至DNA中，或者是乙酰基增加到组蛋白中。
Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.
核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。
Other work has focused on histone acetylation, a chemical modification that unwinds DNA from protein spools called histones, thereby enabling gene activity.
其他的工作集中在组蛋白乙酰化，这种化学修饰可以使DNA从组蛋白缠绕中解离出来，产生基因活性。
DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators.
DNA甲基化由DNA甲基转移酶催化，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。
Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.
表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。
Two forms of DNA damage caused by peroxynitrite are DNA base modification and DNA single strand breakage.
过亚硝酸根对DNA的损伤主要有两种形式：dna碱基修饰与dna单链断裂。
The genotoxicity of arsenic, which includes the modification of DNA, DNA break damages and DNA repair prevention, may be the most important mechanism of arsenic carcinogenesis.
砷的致癌症机制主要有遗传物质修饰、DNA断裂损伤及活性氧生成等。
DNA methylation is the unique natural covalent modification of vertebrate animals.
DNA甲基化是脊椎动物DNA唯一的自然共价修饰方式。
Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
The function of plant genomes depends on chromatin marks such as the methylation of DNA and the post-translational modification of histones.
植物基因组的功能依赖于染色质标记，诸如dna的甲基化和组蛋白的转录后修饰。
Epigenetic variation plays an important role in plant growth and development, including DNA methylation, histone modification, chromosome remodeling, and RNA interference and so on.
表观遗传变异对于植物的生长发育起着重要作用，主要包括DNA甲基化、组蛋白修饰、染色体重塑和RNA干涉等。
DNA methylation is a major epigenetic modification and plays a crucial role in embryonic development and placentas 'development.
DNA甲基化是一种主要的表观遗传修饰，对于胚胎发育、胎盘及胎儿的生长具有重要作用。
DNA methylation is an important epigenetic modification which regulates a number of biological processes.
DNA甲基化作为一种重要的表观遗传修饰，调节着机体许多生物学过程。
DNA phosphorothioate modification exists in a wide variety of bacterial species.
DNA的磷硫酰化修饰广泛存在于细菌中。
Aberrant methylation may be the most common mechanism of inactivating cancer-related genes in lung cancer, and histone modification may be closely associated with DNA methylation.
表遗传学机制在肺癌的形成中占据重要地位，包括DNA的甲基化和组蛋白修饰，肺癌中与癌形成有关基因的失活多与异常甲基化有关，并且组蛋白修饰和甲基化紧密联系着。
Aberrant methylation may be the most common mechanism of inactivating cancer-related genes in lung cancer, and histone modification may be closely associated with DNA methylation.
表遗传学机制在肺癌的形成中占据重要地位，包括DNA的甲基化和组蛋白修饰，肺癌中与癌形成有关基因的失活多与异常甲基化有关，并且组蛋白修饰和甲基化紧密联系着。
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