Memory loss, difficulty in performing familiar tasks, and problems with abstract thinking are all indicators of the beginning of the disease.
记忆力减退、做熟悉的任务出现困难、抽象思考出现问题，这些都是疾病开始的征兆。
"This creates a huge financial difficulty for us because you have to pay your bills, electricity and rent at the beginning of the month," he said in an interview.
“这给我们带来了极大的财政困难，要知道月初时你还得付账单，交房租和电费，”他在采访中说。
It could be difficult to get consistent income in the beginning because of the difficulty to find clients.
因为一开始很难找到客户，所以开始的时候很难得到稳定的收入。
In addition, the beginning investment parameter was defined in measuring the difficulty for each supply chain members to build their reverse channel.
引入初始投入系数，以区分不同供应链成员建立回收通道的难易程度。
At the beginning of 21st century, the difficulty, the complexity of the historical problems and the resentment between two nations have resulted in the charges of their relations.
新世纪伊始，由于中日两国在历史问题上的困难性、复杂性、情绪性，导致中日关系出现新的波折。
At the beginning of 21st century, the difficulty, the complexity of the historical problems and the resentment between two nations have resulted in the charges of their relations.
新世纪伊始，由于中日两国在历史问题上的困难性、复杂性、情绪性，导致中日关系出现新的波折。
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