Conclusion morphine may affect purine nucleotide metabolism of nerve cells, increase the adenylate and adenosine levels, which may be one of the mechanism of morphine dependence and tolerance.
结论：吗啡影响神经细胞嘌呤核苷酸代谢，使细胞内腺苷酸及腺苷水平增高，这可能是吗啡依赖和耐受形成的机理之一。
More than physical tolerance, an addiction develops physical and psychological dependence separate from the need to avoid the pain of withdrawal.
除生理上的耐受(药)性之外，上瘾会形成不同于逃避戒除痛苦需要的生理和心理上的依赖性。
Alcohol dependence is characterized by tolerance (the need to drink more to achieve the same "high") and withdrawal symptoms if drinking is suddenly stopped.
酒精依赖的特点是对酒精的耐受性(酒量越来越大)和突然停止饮酒的戒断症状。
Tolerance and psychological and physical dependence may occur with continuing use.
连续用药可产生耐药性、精神依赖性和躯体依赖性。
Chronic paraldehyde intoxication results in tolerance and dependence.
慢性副醛中毒能导致耐受性和依赖性。
无耐受和依赖性。
Otherwise, the patient can easily produce tolerance and dependence.
否则，极易使患者产生耐受性和依赖性。
Especially, some of them show biphasic modulation on opioid functions, which enhance opioid analgesia, but inhibit tolerance to and substance dependence on opioids.
特别是有些药物能对阿片功能产生双向调节作用，即增强阿片镇痛，对抗阿片耐受和躯体依赖。
Results indicated that melatonin possessed multiple functions within pharmacologic dose without tolerance and dependence in itself.
大量实验证明褪黑素在药理剂量下发挥多种功效，而且其本身并无明显的耐受性和依赖性。
Nitric oxide, an intracellular messenger molecule linked to activation of N Methyl D aspartate(NMDA) receptor, plays a role in morphine tolerance and dependence.
一氧化氮（NO）是与N甲基D 天（门）冬氨酸（NM DA）受体活性相关的一种细胞内信使分子，在吗啡耐受和依赖中起作用。
Chronic paraldehyde intoxication results in tolerance and dependence.
中毒能导致耐受性和依赖性。
Aim To study the role of nitric oxide by measuring the expression and activity of nitric oxide synthase in hippocampus of rats tolerance and dependence to the anticonvulsant action of flurazepam.
目的通过测定大鼠对氟西泮抗痫耐受性和依赖性时海马中一氧化氮合酶（NOS）蛋白表达及活性的变化，探讨一氧化氮（NO）在此过程中可能的作用。方法建立大鼠对氟西泮抗痫耐受性和依赖性的模型。
Aim To study the role of nitric oxide by measuring the expression and activity of nitric oxide synthase in hippocampus of rats tolerance and dependence to the anticonvulsant action of flurazepam.
目的通过测定大鼠对氟西泮抗痫耐受性和依赖性时海马中一氧化氮合酶（NOS）蛋白表达及活性的变化，探讨一氧化氮（NO）在此过程中可能的作用。方法建立大鼠对氟西泮抗痫耐受性和依赖性的模型。
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