Objective To study the variation of HCV 5 '- NCR and core gene in serial sera collected from patients with HCV infection.
目的研究丙型肝炎病人的系列说清中HCV5'-NCR及核心区基因变化。
Among HCV encoding gene, core region shows greater sequence conservation. Core gene expression has favorable antigen stability.
在HCV的编码基因中，核心区(C区)序列具有高度遗传保守性，c基因表达产物具有良好的抗原稳定性。
Methods Serial sera were collected from 4 plasma-donors with HCV infection. 5' - NCR and core gene were amplified, sequenced and analyzed using software.
方法4例因献血感染HCV病人的系列血标本，用特异性引物扩增5'-NCR和核心区基因并进行测序。
ObjectiveAs plasmid with HCV core gene induces only very weak immune responses, enhancement of immune responses by cytokines can be beneficial to HCV vaccine.
目的HCV C蛋白基因诱导的免疫应答较弱，因而增强HCV C蛋白基因免疫对于开发HCV疫苗具有极其的重要性。
Histone is the core of chromatin, and covalent modification of histone tails have fundamental roles in regulation of gene expression.
组蛋白是染色质的核心，其尾部共价修饰在基因表达调控中有重要作用。
Conclusion 5 '-ncr is more conserved than the core region and the genotype is the major cause of gene variation.
结论5′- NCR序列保守性大于核心区。型别是导致基因变化的主要原因。
Gene engineering technology is the core in modern biological technology.
基因工程技术是现代生物技术的核心技术。
Law of changes of gene frequency was core of research on population genetics, was also a key of understanding biological evolution.
基因频率变化规律是群体遗传学研究的核心，也是理解生物进化的关键。
It has been known for some time that the acetylation of N-termini of core histones in nucleosome is associated with gene activation.
人们很早就注意到，真核细胞中核小体核心组蛋白N-端尾部的乙酰化水平与基因活化密切相关。
Objective to explore the possibility of using HBV as a gene delivery vector, and to test the anti-HBV effects by intracellular expression of dominant negative mutants of core protein.
目的探索H BV作为基因治疗载体的可能性及检验HBV点突变表达显性阴性突变体抗hbv的作用。
Conclusion 5 '- NCR is more conserved than the core region and the genotype is the major cause of gene variation.
结论5'-NCR序列保守性大于核心区。型别是导致基因变化的主要原因。
AIM: to construct the recombinant plasmids expressing full-length HCV core protein gene and 3 different deletion mutated hepatitis core protein genes and to express them in E. coli.
目的：构建丙型肝炎病毒(HCV)全长及3种不同缺失突变的核心蛋白基因的原核表达载体，并在大肠杆菌中表达。
Its core areas include: QTL mapping or gene discovery, Marker assisted selection, genomic selection, Genetic engineering, Genetic transformation, Issues in Biosafety and Intellectual Property.
它的核心内容主要包括QTL作图、标记辅助育种、基因组选育、基因工程、遗传转化、生物安全及知识产权问题等。
With the deepening research of gene therapy, to find an efficient, safe, targeted expression gene vector had become one of the core issues of gene therapy.
随着基因治疗研究的不断深入，寻求一种高效、安全、靶向表达的载体已成为了基因治疗的核心问题之一。
With the deepening research of gene therapy, to find an efficient, safe, targeted expression gene vector had become one of the core issues of gene therapy.
随着基因治疗研究的不断深入，寻求一种高效、安全、靶向表达的载体已成为了基因治疗的核心问题之一。
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