In vertebrates, gap junction hemichannels are primarily homo- or hetero-hexamers of connexin proteins.
在脊椎动物中,间隙连接的半通道主要是连接蛋白的同型或异型六聚体。
Immunohistochemical analysis of frozen mouse heart tissue, using Connexin 43 Antibody.
使用Connexin43抗体对冷冻的小鼠心脏组织进行免疫组化分析。
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Connexin 43 Antibody.
使用Connexin43抗体对石蜡包埋的人乳腺癌组织进行免疫组化分析。
Results: Nifedipine promoted junctional communication and expression of connexin 43 in cultured rat SMC.
结果显示,硝苯吡啶促进细胞连接蛋白43的表达和细胞连接通讯。
It may provide a novel therapeutic target for tumor treatment when utilize connexin to design new anti-cancer drug.
将间隙连接作为靶点设计抗癌新药物,将为肿瘤治疗提供新方向。
Results in normal mice, perforin was negative and connexin 43 was located in the intercalated disks of cardiac muscle.
结果:正常小鼠心肌中未见穿孔素阳性表达,连接蛋白43在心肌闰盘中呈阳性表达。
Objective To clone a novel human connexin gene and find out the relationship between this gene and hereditary deafness.
目的利用同源性分析,克隆定位新的人类间隙连接蛋白基因,并探讨该基因和遗传性耳聋的关系。
Objective To evaluate the relationship between changes of connexin protein of gap junction (GJ) and atrial fibrillation.
目的探讨心房肌缝隙连接(GJ)蛋白变化与心房颤动(房颤)间的关系。
PrefaceGap junctions are cell membrane protein channels composed of connexin proteins, which belong to multigene family.
前言缝隙连接是由连接蛋白组成的细胞膜通道,其属于多基因家族。
Benazepril and valsartan can decreased the degree of atrial fibrosis and remodeling of Gap junction connexin effectively.
贝那普利及缬沙坦可有效减轻心房纤维化和心肌缝隙连接蛋白的重构。
Connexin mimetic peptides and connexin permeable tracer molecules were used to gage the presence and function of unpaired connexin hemichannels.
连接蛋白拟似肽和连接蛋白渗透示踪分子过去常用来检测不成对半通道连接蛋白的存在和功能。
METHODS: The expression of connexin 43 and desmin in cardiac muscle cells of mice with experimental viral myocarditis was determined by immunohistochemistry.
方法:连接蛋白43和在实验小鼠病毒性心肌炎心肌细胞结蛋白表达免疫测定。
The immunohistochemical method results showed positive reaction of part of the cell plasm desmin, myocardium specific troponin and connexin-43 after induction.
部分诱导后的细胞胞浆结蛋白,心肌特异性肌钙蛋白,连接蛋白- 43免疫组化呈阳性反应。
Objective: To explore a method of detecting the connexin 43 (Cx43) quantity and distribution by laser scanning confocal microscope (LSCM) with a double label technique.
目的:探讨激光扫描共聚焦显微镜和荧光双重标记技术对心肌连接蛋白43进行定量和定位研究的方法。
Conclusion in viral myocarditis, the expression of connexin 43 in the involved cardiac muscle cells was restrained, that may result in dysfunction of gap junction communication.
结论病毒性心肌炎时受累的心肌细胞连接蛋白43的表达受到抑制可能是导致心肌细胞缝隙连接通讯障碍以致心律失常的一个原因。
Conclusion in myocarditis, expression of connexin 43 and desmin in the involved cardiac muscle cells was inhibited, resulting in dysfunction of gap junctional communication and arrhythmia.
结论病毒性心肌炎时受累的心肌细胞连接蛋白43和结蛋白的表达受到抑制,可能是导致心肌细胞缝隙连接通讯和收缩功能障碍以致心律失常的一个原因。
CONCLUSION: in myocarditis, expression of connexin 43 and desmin in the involved cardiac muscle cells was inhibited, resulting in dysfunction of gap junctional communication and arrhythmia.
结论:在心肌炎,连接蛋白43和结蛋白表达的参与心肌细胞受到抑制,在间隙连接通讯功能障碍引起的心律失常。
Results In normal mice, connexin 43 and desmin are located in the intercalated disks of cardiac muscle, and the latter also revealed a positive immunoreactivity in the cross striations of sarcomeres.
结果连接蛋白43和结蛋白在正常小鼠心肌闰盘中定位分布,均匀存在,后者还在肌节横纹中显示阳性;
RESULTS: in normal mice, connexin 43 and desmin are located in the intercalated disks of cardiac muscle, and the latter also revealed a positive immunoreactivity in the cross striations of sarcomeres.
结果:在正常小鼠,连接蛋白43和结蛋白在心脏肌肉位于闰盘,后者也显示,肌节横纹积极的免疫反应。
RESULTS: in normal mice, connexin 43 and desmin are located in the intercalated disks of cardiac muscle, and the latter also revealed a positive immunoreactivity in the cross striations of sarcomeres.
结果:在正常小鼠,连接蛋白43和结蛋白在心脏肌肉位于闰盘,后者也显示,肌节横纹积极的免疫反应。
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