This paper reviewed the relationship between DNA mismatch repair, chromosome instability and cancer.
本文就DNA错配修复、染色体不稳定和肿瘤之间的联系予以综述。
The length of telomeres gradually decreases with increasing age and cell division number, which can lead to chromosome instability, so the changes in telomere length are closely linked to cell aging.
端粒的长度随着年龄和细胞分裂次数的增加而逐渐变短，因而导致染色体不稳定，因此端粒长度的变化与细胞衰老密切相关。
If not repaired, the breakage can result in lethality or chromosome breakage, and if misrepaired, it can cause mutation, gene instability and the increased rate of tumorigenesis.
双链断裂得不到修复，细胞将会死亡或发生染色体断裂、丢失，若是错误修复将导致基因突变或基因组不稳定，增加癌症的风险度。
Several factors, such as defects in chromosome segregation and DNA damage response, failure of cell cycle checkpoint, telomere dysfunction, may cause chromosomal instability.
多种细胞机制功能障碍将导致染色体不稳定性，包括染色体分离、DNA损伤反应、细胞周期检查点、端粒功能等。
Objective genetic instability is one of the most important factors to underlie neoplasia, and precise segregation of the chromosome is critical for stable inheritance of genetic material.
研究目的遗传的不稳定性是肿瘤生成的最重要的因素之一，而染色体的精确分离是基因物质稳定遗传关键。
The traditional fitness measure is not suitable for the stabilization problem, and therefore we define an instability index which is better and more effective for evaluating the chromosome fitness.
传统的健康度测量方法不适合镇定稳定问题，因此本文定义了不稳定指数，它可以更好地，更有效地评测染色体的健康度。
The traditional fitness measure is not suitable for the stabilization problem, and therefore we define an instability index which is better and more effective for evaluating the chromosome fitness.
传统的健康度测量方法不适合镇定稳定问题，因此本文定义了不稳定指数，它可以更好地，更有效地评测染色体的健康度。
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