Objective: To investigate the roles and relationships among ERK pathway, P53/P21 and CDK5/P35 during neuronal differentiation using a differentiative model of PC12 cells induced by NGF.
目的：利用NGF诱导的PC12细胞分化模型，探讨ERK通路、P53/P21蛋白和CDK5/P35蛋白在神经元分化过程中的可能作用及相互关系。
Increased EGR1 expression activates transcription of other signaling molecules, including CDK5 and tyrosine hydroxylase, and exerts long term effects on neural cell growth and differentiation (2, 3).
增加EGR1表达可以激活其他信号分子的转录，包括CDK5和酪氨酸羟化酶，对神经细胞生长和分化有长期影响(2,3)。
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human CDK5. Antibodies are purified by protein A and peptide affinity chromatography.
该多克隆抗体由合成的人类CDK5氨基酸序列对应肽段免疫动物而制成。该抗体使用蛋白A和多肽亲和层析纯化而得。
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human CDK5. Antibodies are purified by protein A and peptide affinity chromatography.
该多克隆抗体由合成的人类CDK5氨基酸序列对应肽段免疫动物而制成。该抗体使用蛋白A和多肽亲和层析纯化而得。
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