Conclusion: the good effect can be obtained on the buccal adhesive tablets when using CP and HPC (or HPMC) as the adhesive materials.
结论：CP与HPC(或HPMC)作为粘附材料制备丁卡因口腔粘附片能获得良好效果。
CONCLUSION the adhesive property of the tablets and the release behavior of drug are relevant. Also, the formulation of buccal adhesive tablets is optimized by adjusting the composition.
结论口颊黏附片的生物黏附性与体外释药行为具有一定的相关性，通过调整处方可筛选出生物黏附性和体外释药均较理想的处方。
Results:The buccal adhesive tablets of tetracaine prepared by CP and HPC(or HPMC)with 12 produced effect within 1~2min. The adhesive time in oral cavity was more than 3h, and above 10h at night.
结果：用CP与HPC（或HPMC）以12的比率制备的丁卡因口腔粘附片在1～2分钟内起效，口腔内的粘附时间大于3小时，夜间使用可达10小时以上。
Results the adhesive force, dissolution, buccal adhesive test and the clinical curative effect of the tablets were better than those of the films.
结果粘附片剂的粘附力、溶出度、口腔内粘附试验及临床疗效均比粘附膜剂优越。
Results the adhesive force, dissolution, buccal adhesive test and the clinical curative effect of the tablets were better than those of the films.
结果粘附片剂的粘附力、溶出度、口腔内粘附试验及临床疗效均比粘附膜剂优越。
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