She named the still-hypothetical gene BRCA1.
他把这个仍然“假设”的基因命名为BRCA1。
All of the participants carried BRCA1 mutations.
所有的参加者都携带有BRCA1基因突变。
The protein encoded by BRCA1 is involved in DNA repair.
被BRCA1基因编码的蛋白质与DNA修复有关。
My mother has breast cancer and I have the abnormal BRCA1 gene.
我母亲是乳腺癌患者，我的BRCA1基因也不正常。
Researchers say BRCA1 and BRCA2 are very rare among the general population.
研究人员宣称BRCA1和BRCA2在普通人群中罕见。
A simple blood test had revealed that I carried a mutation in the BRCA1 gene.
因为一项简单的血检显示，我的BRCA1基因存在突变。
The interaction between ICAM gene and BRCA1 has some effect on breast cancer risk.
ICAM基因与BRCA1基因间存在相互作用，影响了乳腺癌的危险度。
Women with BRCA1 mutations are at very high risk for breast cancer at an early age.
有BRCA1变异的妇女在早期也有很高的风险可能患上乳腺癌。
Even so, they added, data so far suggests the variants don't modify BRCA1-related ovarian cancer risk.
尽管如此，目前为止的资料显示，这些突变并未改变BRCA1相关的卵巢癌风险。
Objective: To investigate the expression of BRCA1 protein in sporadic ovarian cancer and its significance.
目的：探讨散发性卵巢癌组织中BR CA1蛋白的表达及其意义。
Therefore, the detection of BRCA1 and BRCA2 gene mutation will be valuable for the prognosis of breast cancer.
通过检测乳腺癌患者BRCA1和BRCA2基因的突变情况，将有助于对乳腺癌患者预后的早期评估。
This gene is different from the breast-cancer susceptibility genes, BRCA1 and BRCA2, which women are born with.
这些基因不同于以往的乳腺癌易感基因BRCA1和BRCA2。以往的易感基因是先天具有的。
Conclusions: The mutations of BRCA1 gene are involved in carcinogenesis and development of primary ovarian cancer.
结论：BRCA1基因突变与原发性卵巢癌的发生紧密相关。
Women known to carry a BRCA1 or BRCA2 mutation were identified from an international registry between 1992 and 2003.
该研究通过一个1992-2003年间的国际注册确认那些有BRCA1或BRCA2基因突变的妇女。
The cost of testing for BRCA1 and BRCA2, at more than $3,000 in the United States, remains an obstacle for many women.
测试BRCA1和BRCA2的费用——在美国的的费用要3000多美元（约1.8万元）——将许多女性排斥在外。
Conclusion: the reduction of BRCA1 expression may play an important role in the carcinogenesis of sporadic ovarian cancer.
结论：BRCA1蛋白表达降低在散发性卵巢癌的发病过程中可能具有重要作用。
Jolie carries a 'faulty' gene, called BRCA1, which sharply increases her risk of developing breast cancer and ovarian cancer.
朱莉携带的缺陷基因叫做BRCA1，这一基因会大大增加她罹患乳腺癌和卵巢癌的风险。
But it's far smaller than the fivefold increased risk that comes from inheriting certain mutations in the BRCA1 and BRCA2 genes.
但是，与因继承了乳腺癌易感基因1和乳腺癌易感基因2中的某些基因突变而增加了5倍风险相比，这种冒险是小得多的。
Heredity accounts for about 10% of all breast cancers, and abnormal BRCA1 and BRCA2 genes explain a large number of these cancers.
大约10%的乳腺癌是这一类型，不正常的BRCA1和BRCA2基因是导致这一类型癌症的主要原因。
Of these, 19 patients with a total of 21 tumors had the BRCA1 mutation and eight patients with eight tumors had the BRCA2 mutation.
在这些病患当中，有19病患共有21个肿瘤具有BRCA1突变，八位病患共八个肿瘤具有BRCA2 突变。
Methods The expression of ERCC1, RRM1 and BRCA1 protein in 122 cases of advanced NSCLC was detected by immunohistochemical methods.
方法应用免疫组织化学方法对122例晚期NSCLC组织进行ERCC1、RRM1及BRCA1蛋白表达检测。
In their normal form, BRCA1 and BRCA2 genes prevent breast cancer by producing a protein that stops cells from growing out of control.
在正常形式下，BRCA1和BRCA2基因通过产生阻止细胞生长失控的蛋白质来预防乳癌。
Women carrying a defective copy of the BRCA1 gene have upto an 80 percent lifetime risk of developing the disease, doctors have found.
年夜夫发现，携带出缺陷的BRCA1基因的妇女中，多达80%的人会得乳腺癌。
The researchers found that inactivating the PTEN gene in mice led to the formation of the malignant tumor associated with BRCA1 mutations.
研究者们发现具有PTEN基因活性降低的小鼠会导致与BRCA1突变有关联的恶性肿瘤的形成。
The breast cancer study centered on women who carry a faulty BRCA1 gene, which significantly raises the risk of developing certain cancers.
乳腺癌研究集中在携带有缺陷的BRCA1基因的的女性上，这种基因显著提高患某种癌症的风险。
In normal cells, the BRCA1 protein keeps these regions silent by tagging histones, or DNA packaging proteins, with a molecule called ubiquitin.
在正常细胞中，通过组蛋白标记或DNA包装蛋白，在泛素分子的作用下，BRCA1蛋白使这些区域保持沉默。
Identifying BRCA1 and BRCA2 has led to new techniques for lowering, detecting, and treating breast cancer, and lowering the risk for the disease.
BRCA1和BRCA2基因的发现，为乳腺癌的预防、诊断和治疗带来新的技术方法，还降低了乳腺癌治疗的风险。
Only a fraction of breast cancers result from an inherited gene mutation. Those with a defect in BRCA1 have a 65 percent risk of getting it, on average.
只有一小部分的乳腺癌是由遗传性基因突变造成的。基因brca1有缺陷的人平均患上乳腺癌的几率是65%。
Purpose to estimate the risk for contralateral breast cancer in members of BRCA1 - and BRCA2-positive families and to determine predictive risk factors.
目的在BRCA1和BRCA2基因表达阳性的家族成员中评估对侧乳腺癌的发病风险，以明确预测风险因子。
On average, around 60 percent of women with a family history of the disease who also carry either a faulty BRCA1 or BRCA2 gene will develop breast cancer.
平均大约60%的伴疾病家族史的、携带有缺陷的BRCA1基因或BRCA2基因的女性将患乳腺癌。
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