Origin of humankind is a big difficult problem of science at the present time.
人类起源是当代的一大科学难题。
It is a big difficult problem to repair the crack of gear box if wheel motor in wheel motor repairing.
轮马达齿轮箱裂纹修复是轮马达修理中的一大难题，长期未能解决。
How to treat sludge from sewage treatment plant is a big difficult problem faced by big or middling cities.
如何处置污水处理厂产出的污泥是世界各大、中城市面临的一大难题。
Multitarget interception is a big difficult problem in ballistic missile defense, and is also the most arduous technology of the missile defense system of US.
多目标拦截是弹道导弹防御的重大难题，也是目前美国导弹防御系统所遇到的最大的技术难点。
But, few pay attention to research uncertainty in financial accounting, uncertainty accounting is sure a big difficult problem in accounting which still has so conclusion on the topic.
然而，就财务会计中不确定性问题的研究却屈指可数，可以说会计中的不确定性问题是会计界上的一大难题，是会计学界一个至今尚无定论的课题。
It is a big difficult problem to repair the crack of gear box if wheel motor in wheel motor repairing. This paper makes a systematic statement for the reason and way out of the problem.
轮马达齿轮箱裂纹修复是轮马达修理中的一大难题，长期未能解决。本文系统阐述其产生的原因以及解决办法，对创建无泄漏和现场达标有重要意义。
We are now at the point where the dimensionality and size of the data is a big problem. It makes things computationally very difficult to find these patterns we want to find.
他补充道，“在这里，数据的维数和容量是个大问题，要依靠计算来找到我们想要找寻的模式会变得极为困难。”
Obviously this is a difficult problem, but the incentive to solve it is very big. The main approaches fall into the following categories.
显然，这是一个很困难的问题，但是解决它的激励也很大。
We all know that the strategic decision of the organization, but today, Chinese enterprises are facing a very big problem is that it is difficult to match organizational structure strategy.
大家都知道战略决定组织，但是今天中国企业面临的一个非常大的问题是，恰恰是组织结构战略难以匹配。
It has been a big and difficult problem that the uncontrolled rocket has large dispersion and low firing accuracy.
无控火箭的老大难问题是散布大，射击精度差。
It is definitely difficult for me to get accommodations. I sincerely hope that the company could help solve my big problem. I hereby apply for a dormitory.
住宿对我来说真的很困难，我诚挚地希望公司能够帮助我解决这个大难题，特此向老板申请宿舍。
Self evaluation: in the course of learning interpreting, I have found a very big problem, that is I find it difficult for me to take notes.
自我评价：学习口译的过程中，发现了一个很大的问题，总觉得自己不会记笔记。
Moreover, in our country had realized gradually to the question pressing situation, how carries on the supervision and the control is also a very big technical difficult problem.
此外，在我国已逐渐认识到问题的紧迫性的环境下，如何进行监管和控制也是一个很大的技术难题。
But distilling tower temperature control is a typic big time-lag system, and the control of it is always a difficult problem in coak producing industry.
但由于氨塔温度控制属于典型的大时滞系统，对这种系统的自动控制一直是焦化生产控制中的一个难题。
New village development is not only a big issue but also a difficult problem in China at present.
新农村建设是我国新时期建设的一项大事，同时也是一道难题。
So, always stay in big cities such as Beijing, it will face a lot of very realistic, it is difficult to solve the problem.
所以说，一直待在北京这样的大城市，真的将会面临很多非常现实、难以解决的难题。
Classroom teaching is a kind of traditional way of teaching. Though it has been carried on for many years, the gap between the students has always been a big problem, which is difficult to solve.
班级授课制是传统的教学方法，虽然沿用多年，但一直难以解决学生中存在的较大的差异问题。
The leakage rate of building' s insulation roof is usually high, and its leak renovation problem has been longstanding, big and difficult.
建筑保温屋面渗漏率高，渗漏修缮是个老大难问题。
The leakage rate of buildings insulation roof is usually high, and its leak renovation problem has been longstanding, big and difficult.
建筑保温屋面渗漏率高，渗漏修缮是个老大难问题。
But for people who have a difficult time controlling their movements, this little navigational issue can be a really big problem.
但是对于一些难以控制自己行动的人来说，这个小小的导航问题却是一个大麻烦。
But for people who have a difficult time controlling their movements, this little navigational issue can be a really big problem.
但是对于一些难以控制自己行动的人来说，这个小小的导航问题却是一个大麻烦。
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