The mutations, including in-frame deletions at exon 19 and substitutions at exon 18 or exon 21, cluster around ATP-binding pocket of TK domain.
这些突变均发生在酪氨酸激酶域的ATP结合域附近，突变为19号外显子上的缺失突变，或18和21号外显子上的替代突变。
The conserved surface patch and the deep pocket are responsible for binding to PP2A and ATP, respectively.
这种保守的表面补丁和深口袋负责分别与PP2A和ATP结合。
The conserved surface patch and the deep pocket are responsible for binding to PP2A and ATP, respectively.
这种保守的表面补丁和深口袋负责分别与PP2A和ATP结合。
应用推荐