Dont ask him. It is also at his wits end.
不要问他了，他也不知道。
He seemed to be at his wits end before those ticklish questions.
面对那些棘手的问题他也显得束手无策了。
He was at his wits' end, having worked a year for nothing.
他哭不得笑不得，一年的气力白费了。
Even if the person may be at his/her wits-end handling the individual, just observing from a third party's point of view can give you insights on how to manage.
尽管他们对这些烦人的家伙一点辙都没有，但你只要以旁观者的视角观察，就会想到如何相处的方法了。
And yet another young man jumped to his death within hours of his boss's departure. Foxconn staff say they are at their wits' end.
但就在这位富士康老板离开后数小时，又有一名年轻男性员工跳楼身亡。富士康的管理人员表示，他们已束手无策。
And yet another young man jumped to his death within hours of his boss's departure. Foxconn staff say they are at their wits' end.
但就在这位富士康老板离开后数小时，又有一名年轻男性员工跳楼身亡。富士康的管理人员表示，他们已束手无策。
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