The tumor suppressor gene p53 codes for a transcription factor, p53 protein, plays a critical regulation role in oncogene expression, DNA synthesis and repair systems, and cell apoptosis.
抑癌基因p53编码转录因子p53蛋白在调控癌基因表达、dna合成和损伤修复以及细胞凋亡中起关键作用。
Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). P53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro (2, 3).
p53的激活能够引起细胞周期捕获和DNA修复或细胞凋亡(1)。离体或者在体情况下，p 53可以在多个位点被几个蛋白激酶进行磷酸化(2,3)。
Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). P53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro (2, 3).
p53的激活能够引起细胞周期捕获和DNA修复或细胞凋亡(1)。离体或者在体情况下，p 53可以在多个位点被几个蛋白激酶进行磷酸化(2,3)。
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