Thermostability of enzymes can be altered by single amino acid substitution.
单一氨基酸的置换可以改变酶的热稳定性。
By sequencing the LRP6 gene in affected family members, the scientists found that the mutation caused the substitution of a single amino acid in the protein the gene produced.
通过对影响家族成员的LRP6基因测序，科学家发现了突变导致该基因产生的蛋白其中一个氨基酸替换了。
The five quinazoline compounds were prepared by using 2 amino 4,5 dimethoxy benzoic acid as original material, which underwent ring closing, halogenation and substitution.
方法：以2氨基4 ，5二甲氧基苯甲酸为原料，分别经过环化、氯代、取代等反应，合成了五种目标化合物。
These substitution results in changes in two amino acid residues (Y154H and E348K).
这两个点变异，将导致两个氨基酸的置换(Y154H、E348K)。
These substitution results in changes in two amino acid residues (Y154H and E348K).
这两个点变异，将导致两个氨基酸的置换(Y154H、E348K)。
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