There were no detectable ABCG2 positive cells in normal tracheal epithelium.
正常气管上皮未检测到ABCG2表达。
C6 cell line and human glioblastoma cells contained 1% cells which were ABCG2 positive.
C6细胞系和人胶质母细胞瘤细胞中均发现有1%左右的细胞ABCG2蛋白表达阳性。
There is no correlation between the expression of ABCG2 and the clinic characteristic of PHC.
ABCG2蛋白在PHC癌组织中的表达与PHC的临床病理特征无关联。
Results showed that ABCG2 expression increased megakaryocytic differentiation of K562 cells induced by PMA.
结果显示，ABCG2的表达促进了PMA诱导的K562向巨核系的分化。
ABCG2 is a half ATP-binding cassette (ABC) transporter that facilitates efflux of a wide variety of substrates ranging from natural products to synthetic anticancer drugs.
A BCG2是半ATP结合盒转运体。它可以转运内源性物质和人工合成的抗肿瘤药物等多种底物。
However, mutant ABCG2 can be less efficient at pushing gefitinib out of cells in the intestine, the researchers noted. A buildup of drug within these cells can cause diarrhea.
研究人员指出，突变的ABCG2降低了肠道细胞“泵出”的功能，使得细胞内的药物逐渐累积从而导致腹泻。
[Objective]To investigate and anlysis the cytobiological character of the ABCG2~+ ACC-M and ABCG2~- ACC-M, and provide trial references for carcinoma stem cells of further reseach.
[目的]本研究拟对腺样囊性癌ABCG2~+和ABCG2~-的肿瘤细胞生物学特性进行初步研究和分析，为肿瘤干细胞的进一步研究提供实验参考。
Since diarrhea and skin toxicity limit the use of this drug in some patients, the researchers looked for a specific variation in the ABCG2 gene that could disrupt the function of the ABCG2 protein.
由于腹泻和皮肤毒性限制了此类药物的应用，研究人员期望发现ABCG2基因特异性的突变从而能够阻断ABCG2蛋白的功能。
Since diarrhea and skin toxicity limit the use of this drug in some patients, the researchers looked for a specific variation in the ABCG2 gene that could disrupt the function of the ABCG2 protein.
由于腹泻和皮肤毒性限制了此类药物的应用，研究人员期望发现ABCG2基因特异性的突变从而能够阻断ABCG2蛋白的功能。
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