同时还收集了3种鬼臼毒素类似物。
由此中间体可比较方便地合成鬼臼毒素。
This intermediates can be more convenient synthesis of podophyllotoxin.
应用硼氢化钠还原法合成三个硒代鬼臼毒素衍生物。
Three derivatives of selenoylpodophyllotoxin were composed with the reduce method. The synthetic process is temperate;
结论：该方法测定血清中鬼臼毒素简便易行，准确可靠。
Conclusion: The method is an easy, accurate and reliable way to determine podophyllotoxin in Serum.
测定脂质体鬼臼毒素壳聚糖膜剂中脂质体对鬼臼毒素的包封率。
To observe the podophyllotoxin liposome embedding ratio of liposome podophyllotoxin chitosan film.
目的探讨0 5 %脂质体鬼臼毒素壳聚糖膜剂制备的最佳配方。
Objective To explore the best formula of the 0 5% liposome podophyllotoxin chitosan film.
目的制备两种含有鬼臼毒素(PPT)的脂质体凝胶剂并比较两者的性能。
Objective to prepare two different liposome gels containing podophyllotoxin (PPT) and compare their pharmaceutical properties.
用正交试验筛选鬼臼毒素冻干脂质体的优化工艺，并以HPLC法测定其包封率。
The orthogonal experimental design was used to optimize the preparation of podophyllotoxin freeze-dried liposomes. A HPLC method was used to determine the entrapment rate of the product.
制备鬼臼毒素脂质体混悬液并观察粒径、包封率、稳定性等指标，探讨其中的关系。
Prepare the podophyllotoxin liposomes liquid and observe its diameter, embedding ratio and stability, etc, and discuss the relation among them.
结论：DPPC脂质体包裹鬼臼毒素外用具有更好的皮肤靶向性，是较好的皮肤外用制剂。
CONCLUSION: Podophyllotoxin liposome coated by DPPC is much more targetable to skin and is a fairly good topical preparation for applying on skin.
结果皮肤经微针预处理后进行鬼臼毒素透皮，其透皮速率是未经微针处理皮肤的5～11倍。
RESULTS The permeation rates of podophyllotoxin through the skin pretreated with microneedles are 5-11 times higher than that through the untreated one.
表鬼臼毒素2″，3″二脱氧糖苷的新型胺衍生物，其制备方法其作为药物的应用及其抗癌治疗的应用。
Amine derivatives of epipodophyllotoxin 2', 3'-dideoxyglycosides, preparation method therefor and use thereof as drug and for treating cancer.
方法：观察组大鼠涂抹脂质体鬼臼毒素混悬液(载药量0.5%)，对照组大鼠涂抹0.5%鬼臼毒素酊剂。
Methods 0.5% podophyllotoxin in liposome suspension or in alcohol solution (as control) were applied on the rat skin respectively.
鬼臼毒素sln具有较高的包封率，纳米粒粒径分布均匀，稳定性较好，可能制成一种有希望的皮肤外用制剂。
Podophyllotoxin SLN has high entrapment efficiency, an even distribution in size and a satisfactory stability, indicating that it might be a hopeful skin topical preparation in.
鬼臼毒素及其衍生物是一类具有显著生理活性的木脂素类化合物，其主要生理活性表现为抗肿瘤活性及抗病毒活性。
Podophyllotoxin as well as its derivatives exhibit a pronounced biological activity mainly as antitumor agents, which is a good source of the aryltetralin lignan.
通过上述研究，初步推测中肠肠壁细胞可能是鬼臼毒素的一个主要作用靶标，另外中肠蛋白酶也可能是其的作用靶标之一。
Based on above results, it can be concluded that one of the main action targets of podophyllotoxin was epithelial cells of the midgut, and the protease of midgut may also be one of its action targets.
通过上述研究，初步推测中肠肠壁细胞可能是鬼臼毒素的一个主要作用靶标，另外中肠蛋白酶也可能是其的作用靶标之一。
Based on above results, it can be concluded that one of the main action targets of podophyllotoxin was epithelial cells of the midgut, and the protease of midgut may also be one of its action targets.
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