最新的观点倾向于最大限度抑制靶点的最小剂量。
Latest opinions tend to favor the minimum dose that maximally inhibits the target.
他们需要病情恶化的模型，使他们能够查明药物靶点。
They need to model the progression of the illness so they can pinpoint drug targets.
增加剂量通常导致抑制其它这些药物并不很适合的靶点。
Increasing the dose often leads to inhibition of other targets for which these drugs do not as fit well.
有时候这是有益的，因为这些靶点同样参与肿瘤的进展。
Sometimes this is favorable, as these targets can also be involved in tumor development. In other cases, increasing the dose only leads to an increase in side effects.8, 9, 10.
这些步骤中的任何一个都将成为新药的潜在靶点。
Any one of these steps would be a potential target for new drugs.
除了5 -羟色胺之外，将来的抗抑郁药可能会有不同的靶点。
Future antidepressants might have targets other than serotonin.
这一突破或将最终为肿瘤早期诊断与治疗提供一种新的靶点。
This breakthrough may ultimately provide a new diagnostic or therapeutic target to detect cancer early or stop tumor growth.
该药并未以某个肿瘤细胞为靶点，而是激活免疫系统更好的对抗肿瘤细胞。
It doesn't target a specific part of the cell.Instead, it stimulates the patient's immune system to allow it to better fight the cancer.
该研究也揭示了EGFR通路在胰腺癌的治疗中是一个重要的靶点。
The results also demonstrate that EGFR signaling pathway is an important target in pancreatic cancer.
研究者认为：肌氨酸对肿瘤的转移有促进作用而且是未来潜在开发新药的靶点。
The research suggests that sarcosine plays a role in helping cancer to spread, and may be a potential target for future new drugs.
在不久的将来，这些组分可能成为上述疾病及其他一些疾病介入的新靶点。
In the future, these components may become targets for intervention in these and other diseases.
除了警示吸烟有害健康之外，这项发现可能还能揭示出治疗癌症的新靶点。
Besides serving as yet another warning against smoking, the finding may also point to new targets for cancer drugs.
蛋白偶联受体具有重要的生理功能和病理意义，已成为一类重要的药物靶点。
Protein-coupled receptors are a group of drug targets with important physiological functions and of pathological significance.
但是不管时间有多长，任何药物的结构改变都会改变他们对靶点的作用能力。
Any alteration of a drug's structure, however, will change its ability to interact with its target, regardless of the length of time involved.
在第一个实验里，两组小鼠使用的T细胞是不同的，而靶点肿瘤细胞则是一样的。
In the first set of experiments, the t cells were varied in two groups of mice while the target tumor cells were uniform.
因此，这说明神经酰胺可以作为改善胰岛素反应和控制血糖浓度的一个治疗靶点。
The findings therefore identify ceramide as a target for therapies aimed at improving insulin response and blood sugar control, the researchers said.
首先到达脉冲源的神经元就会和他们的靶点形成突触结合，相比之下，落后者不是繁殖而是退化。
The first to arrive at the pulsating source proceed to form synaptic connections with their targets; any laggards, by contrast, fail to proliferate and instead degenerate.
尽管毒性不是很大，这些药物通常需要在癌症病人身上进行试验，因为该药物的靶点仅表现在病人身上。
Although not very toxic, these drugs often need to be tested in cancer patients, since the target of the drug is expressed only in these patients.
另外，在非肿瘤治疗领域，随着从分子生物学角度更好的理解疾病，对于特定靶点药物的研究有所增加。
Also, in nononcologic therapeutic areas understanding the molecular biology of the disease increases; thus, the chances of developing specific targeted drugs increase.
而弄清楚这些分子的结构有助于科学家们去研究那些由畸形蛋白质引起的疾病，并找出更好的药物靶点。
Figuring out such structures could help scientists learn more about diseases caused by malformed proteins and identify better drug targets.
由于他们多样的信号途径，大约三分之一，也许一半，如今市场上的药物是以这些受体为靶点。
Because of their diverse signaling pathways, approximately one third, and perhaps as many as half, of currently marketed drugs are designed to target these receptors.
今后，Lo和他的团队会继续研究这两种黑素瘤的耐药机制，并研究其他尚未发现的机制，以发现更多治疗靶点。
Going forward, Lo and his team will study the resistance mechanisms of the two subsets discovered and any others uncovered later to perhaps find better targets for therapy.
好的蛋白结构分辨率对于对于很多应用都是非常重要的，包括但不限于虚拟筛选药物靶点与对接程序和蛋白质设计。
Better resolution is important for a number of applications, including but not limited to virtual screening of drug targets with docking procedures and protein design.
发现癌细胞的行为特征，对于从更长远的角度改善对癌症患者的诊断及治疗并确定治疗靶点是极为重要的。
Discovering how these cells operate is vital in improving diagnosis and treatment for the cancer patient in the longer term, and in identifying therapeutic targets.
发现癌细胞的行为特征，对于从更长远的角度改善对癌症患者的诊断及治疗并确定治疗靶点是极为重要的。
Discovering how these cells operate is vital in improving diagnosis and treatment for the cancer patient in the longer term, and in identifying therapeutic targets.
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