基因治疗的关键就是靶基因的选择。
The key to gene therapy is the selection of the target gene.
核受体是配体活化的转录因子，能调控大量的靶基因。
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the activation of a variety of important target genes.
目的 研制石英谐振组合靶基因检测仪自激式振荡电路。
Objective To construct an oscillation circuit for a gene analyzer based on quartz crystal microbalance.
由此可见，反义pna有可能在靶基因区域显著性抑制无义突变。
Thus, it is possible to significantly suppress nonsense mutations within target genes using antisense PNAs.
Nur77结合到特定的DNA分子，导致靶基因的调控(7)。
Nur77 binds to specific DNA elements leading to the regulation of target genes (7).
WIP1最初被认为是电离辐射应激后p 53的靶基因(1)。
WIP1 was initially identified as a p53 target gene, induced in response to ionizing radiation (1).
本文就微小RNA形成过程及对靶基因调控机制的研究进展作一综述。
The review tries to do a short introduction of the research progresses on the regulation mechanism of microRNAs.
其中一个基因romk成为新型高血压治疗的一个特别有前途的靶基因。
And one of the genes, ROMK, has turned out to be a particularly promising target for new high blood pressure therapy.
这些靶基因在乳腺癌细胞核原发瘤中显示了甲基化相关的转录沉默作用。
These target genes displayed methylation - associated transcriptional silencing in breast cancer cells and primary tumours.
拥有治疗靶基因最多的是克罗恩氏病和I型糖尿病，大致分别为9个和7个。
The richest targets were Crohn's disease and type I diabetes, with nine and seven near-certainties respectively.
如果能够找到作用于靶基因的药物，就可以帮助数百万的骨质疏松老年患者。
If we can find a way to get to our target gene with a drug we may be able to help the millions of seniors with osteoporosis.
靶基因的变异表现为置于指示琼脂平板上的蓝色噬菌斑背景下的无色透明噬菌斑。
Mutations in the target gene appear as colorless plaques on a background of blue plaques when plated on indicator agar.
已知有许多的转录因子是非常重要的MAPK靶基因，锌指蛋白就是中间的一类。
Many transcription factors are important MAPK targets, and zinc finger protein is one of them.
目的：探讨维甲酸在预防和治疗肿瘤中的作用机制，分离受维甲酸调控的靶基因。
Objective: To explore the mechanism of prevention and therapy by retinoic acid in cancer and isolate ATRA-target gene and explore the mechanism of expression regulation of mitochondrial gene.
比较了不同的转染方式对靶基因表达的干扰效果，结果证明电击法的效果略优于浸泡法。
We use two different dsRNA deliveries and the result indicated that electroporation was better than soaking.
在染色体中，SATB1还在靶基因位置上通过复活组蛋白修饰酶普遍的调节组蛋白的状态。
SATB1 also globally regulates histone status in the chromatin by recruiting histone-modifying enzymes to the target-gene loci.
研究结果表明，该基因可用于多种肿瘤的诊断标志基因，也可以作为肿瘤基因治疗的靶基因。
The research result shows that: it can be applied to diagnostic sign gene for multiple tumours, and also be used as the target gene for the tumour gene therapy.
该方法的一大特色是，可以通过反应副产物-白色焦磷酸镁沉淀的产生与否判断靶基因的存在。
The favorable peculiarity of this method is that it can demonstrate the absence of the target gene by the production of white precipitate of magnesium pyrophosphate .
细胞核中，抑制素通过与转录因子如rb和p 53相互作用来调节靶基因的转录(2,5)。
In the nucleus prohibitins interact with transcription factors such as Rb and p53 to regulate target gene transcription (2, 5).
这些核激素受体由其配体(激活物)激活后，通过偶联特异的反应元件来调控多种靶基因的表达。
After activation by ligand as is the case with nuclear receptors, PPARs binds to a specific element in the promoter region of target genes.
目的：通过基因芯片技术研究薯蓣皂苷对乳腺癌细胞基因表达的影响，初步探索药物作用的靶基因。
Objective: to study the effect of dioscin to breast cancer cytogene expression by cDNA microarray technique, and to explore target genes of drug action initially.
一个有条件的表达模型用来从足突细胞中删除VEGF基因，在四环素衍生物的出现下靶基因被删除。
A conditional expression model, in which the target gene is deleted in the presence of a tetracycline derivative, was used to delete the VEGF gene from podocytes.
提示- 1892和- 1837两位点虽不在启动子区，但可能对靶基因表达具有一定的远端调控作用。
It suggests that although -1892 and -1837 loci are far from the promoter, they may play a remote regulation on the target gene expression.
前者侧重于小RNA表达的检测和功能机制的阐明，后者则包括新小RNA基因及小RNA靶基因的预测。
The former is involved in miRNA detection and function analysis, and the latter focus on miRNA gene prediction and miRNA targets prediction.
核受体家族的经典作用机制是在其配基存在下结合在靶基因的应答元件上，从而在转录水平上调节基因的表达。
The classical mechanism for nuclear receptors to regulate gene expression is to bind the hormone response element(HRE) on the target gene in the presence of their ligands.
目的以RNA依赖性腺嘌呤脱氨酶（ADAR1）为靶基因优化悬浮培养的小鼠原代淋巴细胞的电穿孔转染条件。
Objective To optimize the electroporation parameters in mouse primary lymphocyte cultured in suspension with adenosine deaminase acting on RNA 1(ADAR1) as a reporter gene.
抑癌蛋白p53通过调节下游靶基因的转录，参与细胞凋亡、细胞周期抑制、DNA损伤修复等多种生物学过程。
The tumor suppressor p53 regulates cell cycle arrest, apoptosis and DNA repair processes by controlling various target genes that contain p53 sequence-specific DNA binding sites.
抑癌蛋白p53通过调节下游靶基因的转录，参与细胞凋亡、细胞周期抑制、DNA损伤修复等多种生物学过程。
The tumor suppressor p53 regulates cell cycle arrest, apoptosis and DNA repair processes by controlling various target genes that contain p53 sequence-specific DNA binding sites.
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