这一细节让他们作出结论:可能是遗传获得的非编码DNA序列、而不是基因变异才使得最大部分的转录因子结合位置发生变化。
This detail led them to conclude that inherited non-coding DNA sequences – not mutations in genes – may drive the lion's share of differences in where transcription factors attach.
然后他们问,是否能在其他动物,或者非动物界中,找到和这三种群体的转录组相似的基因?
They then asked whether similar-looking genes to those in a transcriptome were found more often in other animals, or in non-animals.
研究还表明,即便是母亲无法接受抗逆转录病毒疗法(ART)的非最理想的情况下,纯母乳喂养也大大降低了婴儿感染艾滋病毒的风险。
Research also shows that exclusive breastfeeding greatly reduces the risk of the baby acquiring HIV, even if women are unable to access Antiretroviral Therapy (ART), although this is not ideal.
PCR和测序结果分析,发现这个非编码RNA基因通过选择性剪接产生两种不同的转录产物。
Analysis of RT-PCR and sequencing indicated that the ncRNA gene had two different transcripts through alternatively splicing pattern.
细胞的分化是一个动态的过程,带动激活和抑制特定的基因组,基因组转录活性和非活性染色质域的划分。
Cellular differentiation is a dynamic process driven by activation and repression of specific sets of genes, partitioning the genome into transcriptionally active and inactive chromatin domains.
我们的结果给出了通往直接用实验操作的上千非编码RNA的之路并阐述了从头重新构建哺乳动物转录组的强大能力。
Our results open the way to direct experimental manipulation of thousands of noncodingRNAs and demonstrate the power of reconstruction to render a comprehensive picture of mammalian transcriptomes.
Pfizer的crizotinib专门攻击某种基因转录的蛋白,只有少于5%的非小细胞肺癌患者具有这种基因。 Roche的vemurafenib通过阻断基因B-RAF的变异体抵抗晚期黑色素瘤。
Pfizer's crizotinib attacks a protein encoded by a gene found in fewer than 5% of patients with non-small-cell lung cancer.
Pfizer的crizotinib专门攻击某种基因转录的蛋白,只有少于5%的非小细胞肺癌患者具有这种基因。 Roche的vemurafenib通过阻断基因B-RAF的变异体抵抗晚期黑色素瘤。
Pfizer's crizotinib attacks a protein encoded by a gene found in fewer than 5% of patients with non-small-cell lung cancer.
应用推荐