该药物能够准确的将正确的染色体数目导入每一新细胞，产生非整倍体细胞，能够用于治疗由于肿瘤抑制基因突变导致的肿瘤。
Drugs that inhibit accurate delivery of the right number of chromosomes to each new cell, resulting in aneuploidy, would be used to destroy tumors caused by mutations in the tumor suppressors.
石龙芮染色体非整倍性和染色体异常的观察。
The observation on chromosome aneuploid and chromosome abnormity in ranunculus sceleratus l.
染色体结构改变造成遗传物质的重新排列。若为非平衡型重排，则可导致异常表型。
Rearrangement — Chromosome breakage followed by reconstitution in an abnormal combination. If unbalanced, the rearrangement can produce an abnormal phenotype.
但当哺乳动物为非整倍体时，即每个染色体不再有两个拷贝时，他们通常会长出一个较大的细胞核。
Nevertheless, when mammalian cells become aneuploid - that is, they no longer have two copies of each chromosome - they often grow a larger nucleus.
目前，使用PGD技术，可以测试出许多种不同的疾病，包括非整倍体，单基因病和染色体易位等。
Currently, we are able to perform PGD for many genetic conditions including single gene disorders and chromosome abnormalities.
四倍体育种中染色体组操作的结果除了产生整倍体外，还产生大量的非整倍体。
Manipulation of chromosome in tetraploid breeding resulted in not only euploids, but also a great many aneuploids.
除了正常染色体对以外，还存在有第二种同源染色体的非整倍体状态，被称为三体性。
An aneuploid state in which a third homologous chromosome is present in addition to the normal autosomal pair is called trisomy.
结果显示各类序列的进化水平沿常染色体呈现明显的非均匀性和规律性。
The results show that the evolution levels of each kind of sequences along chromosomes take on obvious heterogeneity and regularity.
而对于多倍体生物，如体细胞中每条染色体具有三个或三个以上的拷贝，二体或双体就是一种非整倍体状况。
For organisms that normally have three or more copies of each chromosome (those that are triploid or above), disomy is an aneuploid chromosome complement.
本文就染色体基因位点与非综合征性唇腭裂致病机制的关系作一综述。
This review will briefly summarize the relation between gene locus in chromosomes and mechanism of pathopoiesis of NSCLP.
目的建立多色荧光原位杂交技术检测人卵细胞染色体非整倍体的方法。
Objective: To establish the method of aneuploidy detection in human oocytes by multicolor fluorescence in-situ hybridization (M-FISH).
结果卵圆细胞在培养过程中倍增时间逐渐缩短，非整倍体染色体数目增加，在软琼脂中生长的克隆增多。
Results During long term cultivation, the population doubling time of the cells became shorter and the percentage of aneuploidy chromosomes and colonies grown in soft AGAR increased.
而在1：0组，照射剂量与估算剂量基本一致。结论染色体畸变可以作为估算非均匀照射的生物学指标之一。
But when the ratio was 1:0, the radiation dose was accordant with the estimated dose. Conclusions Chromosome aberrations could be a biomarker for estimating the uneven irradiation.
非整倍性是指个体的染色体不均衡或者或者某些染色体比正常人的染色体数目多或者少包括唐氏综合症。
Aneuploidy is a chromosomal imbalance of one or a few chromosomes above or below the normal human chromosomal number of 46, which may lead a child to have abnormalities including Down Syndrome.
结果64%的卵细胞核型正常，36%的卵细胞为非整倍体，其中22%为同源染色体不分离，14%为姐妹染色单体非平衡性过早分离。
Results 64% of oocytes were normal, 36% of oocytes were aneuploidy, of which 22% were due to nondisjunction and 14% unbalanced predivision.
方法：我们开发了基于游离DNA定向分析的方法，用于胎儿21号、18号和13号染色体非整倍体的检测。
METHODS: We developed an assay based on the targeted analysis of cell-free DNA for the detection of fetal aneuploidies of chromosomes 21, 18, and 13.
Cleveland教授实验室的研究者建立染色体数目有明显变异的小鼠模型，并分析该非整倍体小鼠模型是否更容易罹患肿瘤。
To find out, researchers in the Cleveland lab created and analyzed mouse models with cells having a highly variable number of chromosomes to discover if such aneuploidy made the mice more tumor-prone.
前言：目的：建立采用第一极体植入前染色体非整倍体诊断的方法。
Objective: To establish the method of preimplantation genetic diagnosis (PGD) by use of first polar bodies.
非整倍的染色体突变才是真正的诱因，因为它破坏了染色体的类型。
Chromosomal mutation, called aneuploidy, is the cause instead, and it destabilizes chromosomal patterns.
端粒是保护染色体末端的非编码重复DNA序列。
Telomeres are sections of noncoding, repeating DNA that protect chromosome ends.
结果表明，昆明山海棠和丙烯酰胺诱导的由整条染色体组成的微核分别可达70.7％和65.9％，提示昆明山海棠和丙烯酰胺均有较强的非整倍体毒性。
The results showed that 70.7% of THH-induced MN and 65.9% of AA-induced MN contained whole chromosomes, suggesting both THH and AA have aneugeni…
研究发现，与非多能性的细胞样品相比，具有多能性的细胞样品在亚染色体的拷贝数存在高频率的变化差异，这些变化集中在特定的基因组区域。
We report a higher frequency of subchromosomal copy number variations in pluripotent samples compared to nonpluripotent samples, with variations enriched in specific genomic regions.
研究发现，与非多能性的细胞样品相比，具有多能性的细胞样品在亚染色体的拷贝数存在高频率的变化差异，这些变化集中在特定的基因组区域。
We report a higher frequency of subchromosomal copy number variations in pluripotent samples compared to nonpluripotent samples, with variations enriched in specific genomic regions.
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