目的研究潜溶剂和环糊精对难溶性药物的联合增溶作用。
Aim To investigate the combined effect of cosolvent and cyclodextrin (CD) on solubilization of insoluble drugs.
目的探讨稀释剂对难溶性药物的hpmc骨架片释药的影响。
OBJECTIVE the effect of different diluents on the release rate of insoluble drug from HPMC hydrogel matrix was investigated.
该系统在国外广泛用于难溶性药物的增溶，而在国内研究得较少。
This system is generally used for solubilization of indissolvable drugs, and research less at home.
该嵌段共聚物微球能提高蛋白、多肽的稳定性，有利于难溶性药物释放。
The microspheres of PEG-PLA block copolymers can enhance the stability of protein and polypeptide, and profit the release of poorly water-soluble pharmaceuticals.
目的 将难溶性药物阿德福韦酯制备成固体分散体，以增加体外溶出度。
Objective To prepare adefovir dipivoxil solid dispersion from poorly-soluble adefovir dipivoxil so as to improve its dissolution rate in vitro.
由于固体抗粘剂多具有极大的比表面积和空隙率，对难溶性药物有一定的分散作用。
And Aerosil could be used as dispersing agent due to its large specific surface area, high porosity and unique adsorption properties.
目的比较不同致孔剂及其用量对水难溶性药物布地奈德肠溶缓释微丸释药行为的影响。
OBJECTIVE To compare the influence of different pore-forming agents and their amount on the release of budesonide enteric-coated sustained-release pellets.
目的：探讨溶出介质的离子强度对难溶性药物的丙基甲基纤维素(HPMC)骨架片释药的影响。
OBJECTIVE To study the effect of ionic strength on insoluble drug release from HPMC hydrogel matrix.
目的：考察水溶性联合载体在增加难溶性药物的溶出速率上是否优于单一载体，并制备速释型固体分散体。
Objective: to investigate whether the combined carrier is superior to the single carrier in improving dissolution of poorly insoluble water drug and prepare a fast released solid dispersion.
由于环糊精外部多羟基的亲水性，使形成的包合物具有良好的可润湿性，从而达到对难溶性药物的增溶效果。
For the exterior hydrophilic surface of CDs, inclusion complexes can have a good wettability, which will improve the water solubility of the poorly soluble drugs.
由于环糊精外部多羟基的亲水性，使形成的包合物具有良好的可润湿性，从而达到对难溶性药物的增溶效果。
For the exterior hydrophilic surface of CDs, inclusion complexes can have a good wettability, which will improve the water solubility of the poorly soluble drugs.
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