本发明公开了一种制备阿达帕林的方法。
阿达帕林及维生素E的复方乳膏剂的制备方法包括：油相和水相的制备；
The preparation method of the adapalene-vitamin E compound cream comprises: preparing an oil phase and a water phase;
目的总结阿达帕林凝胶治疗寻常痤疮的临床文献，为临床合理用药提供参考。
Objective To summarize the experience with adapalene in the treatment of acne vulgaris and to provide a clue to improve the clinical use of adapalene in acne vulgaris.
对溴苯酚经烷基化、硫酸二甲酯醚化、缩合及水解反应制得阿达帕林，总收率51%。
Adapalene was synthesized from 4-bromophenol by alkylation, etherification, condensation and hydrolysis with an overall yield of 51%.
结论阿达帕林凝胶治疗轻中度痤疮安全、有效，可单独或联合用药，还可作为维持治疗。
Conclusions Adapalene is safe and effective for the treatment of mild to moderate acne vulgaris, and can be used as monotherapy, maintenance treatment, or in combination therapy of acne vulgaris.
结论阿达帕林凝胶治疗轻中度痤疮安全、有效，可单独或联合用药，还可作为维持治疗。
Conclusions Adapalene is safe and effective for the treatment of mild to moderate acne vulgaris, and can be used as monotherapy, maintenance treatment, or in combination therapy of acne vulgaris.
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