目的：优化阿立哌唑的制备工艺。
Objective: To optimize the preparation procedure of aripiprazole.
目的：比较阿立哌唑与泰必利治疗儿童抽动障碍的疗效和安全性。
OBJECTIVE: To evaluate the efficacy and safety of aripiprazole in the treatment of tic disorder when tiapride is used as a control.
本发明涉及药物合成领域，公开了阿立哌唑的制备新方法及其中间体。
The invention relates to the field of medicine synthesis and discloses a novel preparation method and an intermediate for aripiprazole.
结果阿立哌唑总收率为81%，经元素分析、红外光谱确证化学结构正确。
Results Aripiprazole was confirmed by elemental analysis and IR. The total yield was 81%.
结论：阿立哌唑合并氟西汀治疗难治性抑郁症的疗效优于单用氟西汀，且耐受性好。
Conclusion: the combination of aripiprazole with fluoxetine is better than aripiprazole alone in the treatment of treatment resistant depression.
目的探讨氯米帕明联合小剂量阿立哌唑治疗恶劣心境障碍患者躯体症状的临床效果。
Objective To explore the curative effectiveness of clompramine combined with low dose of aripiprozole in physical symptoms of patients with dysthymia.
结论：合并小剂量阿立哌唑治疗抗精神病药所致高催乳素血症的长期效应好，安全性高。
CONCLUSION Combined a low dose aripiprazole to long term treatment for schizophrenia patient antipsychotics-induced hyperprolactinemia is effective and safe.
目的：观察小剂量阿立哌唑治疗注意缺陷与多动障碍(ADHD)的临床疗效及不良反应。
Objective: To observe the efficacy and safety of small doses of aripiprazole in the treatment of attention deficit and hyperactive disorder (ADHD).
齐拉西酮组总不良反应发生率为42.4%，阿立哌唑组总不良反应发生率为57.6%。
The incidence rate of adverse effect is 42.4% in Ziprasidone group and that is 57.6% in Aripiprazole group.
目的：观察阿立哌唑治疗儿童孤独症和精神发育迟滞的多动及冲动等行为障碍的疗效及不良反应。
Method:Forty-eight children and adolescents diagnosed with autism or mental retardation accompanying with behavior disorder were treated by aripiprazole.
结论阿立哌唑与利培酮治疗精神分裂症疗效均好、副反应少，可根据疗效和反应程度不同选择使用。
Conclusion Both of Aripiprazole and Risperidone show good effect and less side effects on Schizophrenia, so we can choose anyone according to curative effect and reaction degree.
结果通过优化条件合成了阿立哌唑，总收率40%，目标化合物的结构经元素分析、质谱、氢谱、红外光谱确证。
The structure of the target compound was confirmed by MS, 1H-NMR, IR spectra and elemental analysis.
以2,3 -二氯苯胺为原料，经3步亲核取代反应合成了阿立哌唑。3步反应的收率分别为83%，91%和90%；总收率68%。
Aripiprazole in overall yield of 68% was synthesized from 2, 3-dichloroaniline by a three-step nucleophilic substitution reaction in yield of 83%, 91% and 90%, respectively.
以2,3 -二氯苯胺为原料，经3步亲核取代反应合成了阿立哌唑。3步反应的收率分别为83%，91%和90%；总收率68%。
Aripiprazole in overall yield of 68% was synthesized from 2, 3-dichloroaniline by a three-step nucleophilic substitution reaction in yield of 83%, 91% and 90%, respectively.
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