目的：建立血浆中阿替洛尔的固相萃取结合HPLC检测方法。对两厂家产阿替洛尔片人体相对生物利用度及生物等效性进行评价。
Objective: to establish a method to determine atenolol concentration in plasma by SPE-HPLC, and to study relative bioavailability of atenolol tablet.
结论用酒石酸提高阿替洛尔的溶解能力并进而制备单层芯渗透泵片的方法是可行的。
CONCLUSION it was feasible to enhance the soluble ability and prepare the monolithic osmotic pump tablet of atenolol with tartaric acid.
结论用酒石酸提高阿替洛尔的溶解能力并进而制备单层芯渗透泵片的方法是可行的。
CONCLUSION it was feasible to enhance the soluble ability and prepare the monolithic osmotic pump tablet of atenolol with tartaric acid.
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