目的利用大鼠异位心脏移植模型，探讨门静脉注射供体脾细胞诱导免疫耐受的机制。
Objective on the rat model of heterotopic heart transplantation, the mechanism of immune tolerance induced by portal venous injection of donor spleen cells was studied.
结论经门静脉注射两种或两种以上供体活细胞可减轻慢性排斥反应，VEGF、ET-1的表达与血管硬化及纤维化程度呈正相关。
Conclusions Injection of two or more kinds of donor live cells may alleviate chronic rejection via decreasing of expressions of VEGF and ET-1 in the grafts.
结论经门静脉注射两种或两种以上供体活细胞可减轻慢性排斥反应，VEGF、ET-1的表达与血管硬化及纤维化程度呈正相关。
Conclusions Injection of two or more kinds of donor live cells may alleviate chronic rejection via decreasing of expressions of VEGF and ET-1 in the grafts.
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