目的确定国产乙肝血源疫苗低剂量免疫保护持久性及用重组酵母乙肝疫苗加强免疫的免疫应答。
Objective To determine the persistence of immune protection of China-made, plasma-derived hepatitis B vaccine in infants and the time table of booster immunization.
评价接种酵母重组乙肝疫苗（基因疫苗）的免疫效果与免疫持久性，为基因疫苗的推广应用及高危新生儿乙型肝炎的预防提供依据。
To assess the immunogenecity and efficacy of the yeast recombinant hepatitis B vaccine (YHB vaccine) for the prevention of hepatitis B in the newborns.
目的：探讨重组酵母乙肝疫苗新生儿接种后抗体应答持续时间，强化复种的必要性。
Objective:To investigate the antibody response to hepatitis B vaccination and the necessity of reinforcement of recombinant hepatitis B vaccine (RHBV) at 12 month.
HEV结构区ORF2蛋白在甲醇营养型酵母中的成功表达，以及初步纯化得到的具有强免疫学活性的重组蛋白，为研制新型戊型肝炎基因工程疫苗奠定了基础。
The successful expression of HEV ORF2 protein in p. Pastoris and the production of recombinant protein provides basis for genetically engineered vaccine development of hepatitis E.
HEV结构区ORF2蛋白在甲醇营养型酵母中的成功表达，以及初步纯化得到的具有强免疫学活性的重组蛋白，为研制新型戊型肝炎基因工程疫苗奠定了基础。
The successful expression of HEV ORF2 protein in p. Pastoris and the production of recombinant protein provides basis for genetically engineered vaccine development of hepatitis E.
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