亲水凝胶骨架缓释片的释药过程与相转变过程、凝胶层屏障及区域前沿移动行为密切相关。
The phase transition, barrier function and front movement of the gel layer are closely related to drug release process of hydrophlic gel matrix sustained-release tablets.
目的：制备双氯芬酸钠(DCF)亲水凝胶骨架片，并对其释药影响因素进行了研究。
OBJECTIVE: to make diclofenac sodium (DCF) hydrophilic matrix tablets and examine the factors affecting their dissolution rates.
目的制备丁香苦苷亲水凝胶骨架片，并对其释药影响因素进行了研究。
ObjectiveTo make Singopicroside hydrophilic gel matrix tablets and to examine the factors affecting their dissolution rates.
结果 ：亲水凝胶材料含量越小 ，盐酸地匹福林从凝胶基质中释放越快 ，凝胶体外释药符合一级释放动力学方程 ，离体角膜渗透行为符合一级释放规律。
The cornea permeation test of formulation was studied by using rabbit corneas. Results:The formulation release behavior in vitro followed the first order kinetic equation.
结果 ：亲水凝胶材料含量越小 ，盐酸地匹福林从凝胶基质中释放越快 ，凝胶体外释药符合一级释放动力学方程 ，离体角膜渗透行为符合一级释放规律。
The cornea permeation test of formulation was studied by using rabbit corneas. Results:The formulation release behavior in vitro followed the first order kinetic equation.
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