发现固定化细胞的青霉素酰化酶比天然细胞的更稳定。
It was found that penicillin acylase activity of the immobilized cells was more stable than that of the intact cells.
这表明酶基酰化酶构象的完整性是酶具有催化活力的基础。
This suggests that conformational integrity of aminoacylase appears to be essential for its catalytic activity.
本发明公开了一种小粒径窄分布青霉素酰化酶固定化载体的制备方法。
The invention discloses a small particle size narrow distribution penicillin acylation enzyme fixed carrier preparation method.
同时介绍了固定化青霉素酰化酶和固定化脂肪酶在工业催化领域的应用。
The main applications of immobilized penicillin G acylase and lipase in industrial catalysis were introduced as well.
认识到开发新颖治疗剂的要求，本发明提供新颖组蛋白去乙酰化酶抑制剂。
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors.
利用X射线微区分析 ，对固定化青霉素G酰化酶的活性进行了定位分析。
The localization of activity of immobilized glucose oxidase (GOD) was studied by X ray microanalysis.
本研究是对推测的小麦组蛋白乙酰转移酶及脱乙酰化酶基因功能研究的首次报道。
This is a first report about function study of histone acetyltransferase and deacetylase in wheat.
靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。
Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
建立以氯霉素乙酰化酶(CAT)为报告基因的雄激素受体(AR)报告基因试验。
To develop an androgen receptor (AR) reporter gene assay in which the reporter gene is chloramphenicol acetyltransferase (CAT).
目的研究组蛋白去乙酰化酶抑制剂MS275对人多发性骨髓瘤细胞U266增殖的影响。
ObjectiveTo investigate the antitumor effect of MS275, a histone deacetylase inhibitor, on growth of the human myeloma cell line U266.
抗肿瘤药罗米地辛是一种有效的组蛋白去乙酰化酶抑制剂，临床 上用于治疗皮肤T细胞淋巴瘤。
Romidepsin is a potent histone deacetylase inhibitor, and is used in the treatment of cutaneous T-cell lymphoma (CTCL).
发酵过程中维持低葡萄糖水平可以限制细胞的生长速率，提高质粒稳定性和促进青霉素G酰化酶的合成。
Methods:The influence of ammonium sulfate and glucose on plasmid stability and penicillin G acylase activity were conducted in flask shakes and a 5L fermentor.
组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。
The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other, which are histone transacetylase and histone deacetylase.
目的：探讨组蛋白去乙酰化酶抑制剂MS- 275诱导人多发性骨髓瘤细胞株u266凋亡的分子机制。
OBJECTIVE: to investigate the molecular mechanisms of histone deacetylase inhibitor MS-275 on apoptosis of human myeloma U266 cell line.
本文主要就组蛋白乙酰转移酶调节基因转录以及组蛋白去乙酰化酶抑制剂促进记忆形成的作用机理进行综述。
In this paper, we reviewed the mechanisms on histone acetyltransferases regulating gene transcription and histone deacetylase inhibitors promoting memory formation.
他们发现，大脑中有一个“开关”控制瘦素的作用，它就是一种名为组蛋白去乙酰化酶5（HDAC5）的酶。
They have discovered an enzyme - histone deacetylase 5 (HDAC5) - has a significant influence on the effect of the hormone.
从土壤的选择性培养液中提取微生物的DNA，通过PCR的方法直接扩增成功得到GL-7-ACA酰化酶基因。
The genomic DNA was extracted from the selective cultures and the GL-7-ACA acylase gene was directly amplified by PCR technique.
我们期望，本次会议将评估去乙酰化酶生物学相关性的各种人类的条件，并提供一个独特的环境讨论特异性治疗策略。
We envision that this meeting will evaluate the relevance of sirtuin biology in various human conditions, and provide a unique environment for discussing specific therapeutic strategies.
结论6APA生产中使用新的固定化青霉素酰化酶反应器将提高6 APA的收率，减少固定化青霉素酰化酶的损耗。
Conclusions the usage of the new immobilized penicillin acylase reactor in the 6-apa production will result in a higher yield of 6-apa and lower loss of immobilized penicillin acylase.
本文综述了丁酸和植物提取物等饲料添加剂作为组蛋白去乙酰化酶(HDAC)抑制剂在模型动物及畜禽上的研究进展。
This review focused on the advances of the effect of feed additives, such as butyrate and plant extracts, on model animal and livestock as inhibitors of histone deacetylases (HDAC).
通过微水相优化拆分制备S-2-苯基丙酸的反应条件，确定了青霉素酰化酶拆分制备S-2-苯基丙酸的最佳工艺参数。
S-2-phenylpropionic acid was obtained by hydrolysis of 2-phenylpropionic ester catalyzed by penicillin G acylase (PGA) in the micro-aqueous phase.
以Y型分子筛为载体，分别采用吸附法、吸附-戊二醛交联法、偶联法和偶联-重氮法4种方法对氨基酰化酶i进行固定化。
Acylase I was immobilized on Y-type molecular sieve by using 4 kinds of methods, namely, adsorption, adsorption-crosslink, coupling and coupling-diazotization.
研究人员经过实验发现，通过去除哺乳动物细胞中的PSF或sin3 -组蛋白去乙酰化酶复合物，他们能够缩短生物钟周期的长度。
The researchers found that they could shorten the length of the circadian cycle by removing PSF or SIN3-histone deacetylase complex from mammalian cells.
Rattan博士认为老化是损伤的不断积累，而且老化并未从基因上得到严格的控制。他说，去乙酰化酶也许只是更纷繁复杂的情形中很小的一部分。
In his view, ageing is about the accumulation of damage, and is not under tight genetic control. Sirtuins will, he says, probably be but a small part of a more complicated picture.
综述了青霉素乙酰化固定化酶和头孢氨苄酶法缩合工艺的研究进展；
The advances in immobilized acetylase of penicillin and process of enzymatic condensation in cephalexin synthesis were reviewed.
背景：胆碱乙酰化转移酶是乙酰胆碱合成的关键酶，是胆碱能神经系统功能活动的重要标志。
BACKGROUND: the choline acetyltransferase (ChAT) is the key synthetic enzyme for acetylcholine, and is the important symbol of the functional activity of the cholinergic system.
本文主要介绍了磷脂的化学改性方法，例如：羟基化、氢化、酶水解、酰化等。
The methods of the modification of phospholipids were summarized, such as hydroxylation, hydrogenation, hydrolyzation, acetylation, and so on.
组蛋白去乙酰酶抑制剂可提高组蛋白的乙酰化水平，并对一些非组蛋白成分产生影响，从而调节某些特定基因的表达。
Histone deacetylase inhibitors increase the acetylation level of histone as well as some non-histone proteins, and specifically modulate some gene expression.
组蛋白乙酰转移酶和组蛋白去乙酰酶活性共同决定了组蛋白的乙酰化水平。
The level of his-tone acetylation is determined by the activities of histone acetyltransferases and histone deacetylases.
组蛋白乙酰化与基因转录等生物效应有密切的关系，组蛋白乙酰化主要是由组蛋白乙酸转移酶催化的。
Histone acetylation has a close relation with some biological effects such as gene transcription, and is catalyzed by histone acetyltransferases.
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