获取人蛋白酪氨酸磷酸酯酶4A2（PTP4A2）基因并高效表达纯化，对于产物的体外活性进行测定。
To obtain human protein tyrosine phosphatase type 4A2 (PTP4A2) gene expressed in E. coli and purify the target proteins.
本发明中的溴酚类化合物具有蛋白质酪氨酸磷酸酯酶(PTP1B)抑制活性，可用于治疗2型糖尿病和肥胖症。
The bromophenol compounds of the invention have inhibitory activity against protein tyrosine phosphatase (PTP1B), and can be used for treating the type 2 diabetes and the obesity.
介绍了最近几年来关于酪氨酸蛋白磷酸酯酶1B作用的机制以及通过各种途径发现的结构新颖的小分子抑制剂的构效关系研究进展。
The advances made in the new compounds identified as Protein Tyrosine Phosphatases 1B (PTP1B) inhibitors recently and their structure-activity relationship were reviewed in this paper.
酪氨酸蛋白磷酸酯酶1 B在胰岛素依赖的信号传导途径中发挥着非常重要的作用，并作为一个潜在的治疗2型糖尿病和肥胖的作用靶点日益受到广泛的关注。
PTP1B plays a very important role in the insulin-dependent signaling cascade and has attracted considerable attention as a possible target for the treatment of type 2 diabetes and obesity.
酪氨酸蛋白磷酸酯酶1 B在胰岛素依赖的信号传导途径中发挥着非常重要的作用，并作为一个潜在的治疗2型糖尿病和肥胖的作用靶点日益受到广泛的关注。
PTP1B plays a very important role in the insulin-dependent signaling cascade and has attracted considerable attention as a possible target for the treatment of type 2 diabetes and obesity.
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