当改变DNA链的浓度时，也会有相似的响应，(DNA链)也可以用其他类型的配体-受体对替换，例如抗体。
A similar response is expected by changing the concentration of the DNA tethers, which could also be replaced by other types of ligand-receptor pairs, such as antibodies.
一旦更多了解受体、配体的相互作用以及从对靶子在溶液中的特性的高分辩率研究中获得更多的信息，人们就可以设计出更好的药物。
Better drugs will be designed once more is understood about receptor-ligand interactions and more information about targets is available from high-resolution studies of their properties in solution.
使用单配体配方不仅会导致靶向KB细胞活性的减少（增强了毒性），同时也使含有靶向受体的非靶向细胞活性降低。
Use of single-ligand formulations led to a reduction in viability (increased toxicity) not only in target KB cells but also in off-target cells with the targeted receptor available.
接着，我们检测配体依赖的基于受体表达，磷酸化，二聚化的细胞对吉非替尼敏感的机制。
Subsequently, we monitored the ligand-dependent HER profiles based on receptor expression, phosphorylation, and dimerization in conjunction with measurements of cellular susceptibility to gefitinib.
化疗药物联合过氧化物酶体增殖物激活受体(PPAR)的配体能够协同抑制肺细胞癌及卵巢癌细胞。
Chemotherapy given in combination with ligands for the peroxisome proliferator-activated receptor - (PPAR) synergistically inhibits the growth of lung and ovarian cancer cell lines.
细胞对外界信号可能会发生不同的反应，但这些反应都源自，配体和受体结合这个简单的化学过程。
There's a diverse range of responses that might occur, but that response is initiated by this simple chemical process of a ligand binding to a receptor.
当一种受体与其相应的配体相遇，经细胞膜传递信号，随后启动下一个反应。
When one of the receptors encounters such a molecule, it relays a signal across the cell membrane that, in turn, initiates a response.
多巴胺受体根据其对腺苷酸环化酶活力的不同影响及具有专一性配体分为D 1样和D2样两型。
Dopamine receptors are classified into D1 and D2 types based upon their effects on adenylate cyclase activity and their specific ligands.
目的确定人成纤维细胞生长因子受体1 (FGFR1)的配体精细结合位点。
Objective to determine fine binding site of ligand to fibroblast growth factor receptor 1 (FGFR1).
提示层粘连蛋白受体和配体的相互作用可影响胃癌的生长方式。
Suggesting that the interaction between the laminin receptor and its ligand may influence the mode of growth in GC.
自然杀伤细胞通过其表达的不同类型的受体选择性识别细胞表面的相应配体，提供自然杀伤细胞反应的自我调节信号。
Different types of receptors expressed by natural killer (NK) cells may selectively recognize their specific ligands on some other cells and provide self-regulatory signals to control NK responses.
胍丁胺是左旋精氨酸在左旋精氨酸脱羧酶催化下脱羧基的产物，是咪唑啉受体的内源性配体。
Agmatine formed by the decarboxylation of L-Arginine by the enzyme L-arginine decarboxylase, has been postulated to be an endogenous ligand for imidazoline receptors (I-R).
应用亲和毛细管电泳(ace)分析方法，对表皮生长因子受体(EGFR)和新多肽配体GE11之间的结合能力进行分析。
The binding ability of new peptide ligand GE11 and epidermal growth factor receptor (EGFR) was analyzed by affinity capillary electrophoresis (ACE) method.
方法应用放射免疫法(RIA)和放射配体受体法。
Methods Radioimmuniassay (RIA) and radioligand receptor assay were used.
建立具有正常极低密度脂蛋白（VLDL）受体结合功能的小分子受体片段模型并借助此模型研究VLDL受体与配体结合的作用机制。
The purpose of the paper is to build a module of small molecular receptor fragments charactering normal VLDL-R binding function and study the mechanism of VLDL-R binding to ligand.
越来越多研究显示晚期糖化终产物受体（RAGE）与其配体反应在炎症及免疫反应中起重要作用。
There is a growing body of evidences showed that the reaction of receptor for advanced glycation end products(RAGE) with it's ligands was important in inflammatory and immune response.
目的：阐述组胺h 4受体配体的研究进展。
Objective to review the research on histamine H4 receptor ligands.
突变受体功能下降或丧失是由于与配体结合改变或在膜上表达缺陷。
The mutant TSHRs show reduced or no function because of either altered ligand binding or defect in membrane expression.
其方法的核心是对受体-配体相互作用的研究。
The kernel of the methodology focus on the studies of the interactions between receptor and ligand.
已发现几种SARM化合物具有意外的雄激素受体之非甾族配体的促雄性和合成代谢活性。
Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor.
表皮生长因子受体（EGFR）及其配体的过表达与疾病的迅速进展和对化疗的耐药有密切的联系。
The overexpression of the epidermal growth factor receptor and its ligands correlates with rapidly progressive disease and resistance to chemotherapy.
为明确人体胃组织是否存在褪黑素受体(MR)，应用放射配体结合法检测人体胃组织MR特异结合量。
To determine whether melatonin receptors (MR) exist in human stomach, specific binding of melatonin receptor in human stomach was measured by radioligand binding assay.
本文就近年来有关该受体的结构、分布、调节、配体及其在动脉粥样硬化中的作用的研究作一阐述，以便进一步了解动脉粥样硬化的发生机制，探索防治途径。
The structure, distribution, regulation, ligand and function will be elaborated in this article, to find out the mechanism of Atherosclerosis and to explore the way of prevention and treatment.
它们的这些生物学功能是通过配体与受体结合的方式来发挥的，而CXCR3与CCR5是RA中趋化因子的标志性受体。
All of these biological effects are performed by binding of ligands to receptors. Elsewhere, CXCR3 and CCR5 are mark chemokine receptors in RA.
全文就新近发现的趋化因子受体CCR7及其配体CCL21和CCL19的研究进展作一综述。
The aim of this article is to review recent development of CCR7, a newly identified chemokine receptor, and its ligand CCL21and CCL19.
其方法的核心是对受体-配体相互作用的研究。
The kernel of the methodology focuses on the studies of the interactions between receptor and ligand.
因此，深入研究核受体及其配体的作用将为慢性气道炎症性疾病展现广阔的治疗前景。
Therefore, further investigation of nuclear receptors and their ligands may reveal a novel potential therapeutic prospect for chronic airway inflammation.
因此，深入研究核受体及其配体的作用将为慢性气道炎症性疾病展现广阔的治疗前景。
Therefore, further investigation of nuclear receptors and their ligands may reveal a novel potential therapeutic prospect for chronic airway inflammation.
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