中药资源丰富,作用靶点多,可针对多药耐药机制复杂的特点,现有研究亦提示开发中药肿瘤多药耐药逆转剂有较好的前景。
And many researchers pay attention to natural drugs. Traditional Chinese medicine has plentiful resource and multitarget, and it can aim directly to the complicated mechanisms of MDR.
目的研究川芎嗪脂质体在体外对肿瘤细胞的细胞毒作用和对多药耐药的逆转作用,并研究脂质体剂型对上述作用的影响。
Objective: to study the cytotoxic effect of ligustrazine liposomes on tumor cell in vitro and the reversing effect on the MDR, and explore the influence of dosage form on the above effects.
蛋白酶体抑制剂可选择性地促进肿瘤细胞凋亡,逆转多药耐药。
Proteasome inhibitors can selectively promote the apoptosis of tumor cells and overcome MDR.
目的:探讨消化道肿瘤的多药耐药机制和逆转策略。
Aims: To study the multi-drug resistance mechanism of digestive tract tumors and its reverse strategy.
文章重点综述目前研究较多的多药耐药机制,并对肿瘤耐药逆转进展作简要介绍。
This paper provides a review on the hotspots of current MDR research. Moreover, the recent progress in the field of MDR reversal is also briefly introduced.
逆转肿瘤细胞多药耐药旨在全部或部分恢复肿瘤细胞对化疗药物的敏感性,已成为肿瘤mdr研究的热点。
The aim of reversing MDR of gastric cancer cells is to entirely or partly recovery their chemotherapy to drugs, which has become a hot spot in solid tumor MDR research nowadays.
目的探讨本芴醇衍生物LY980 5 0 3对肿瘤多药耐药的逆转作用及其作用机理。
AIM To investigate the reversing effect of LY980503 (a benflumetol derivative) on multidrug resistance of MCF/Dox cell line and its mechanism.
目的探讨本芴醇衍生物LY980 5 0 3对肿瘤多药耐药的逆转作用及其作用机理。
AIM To investigate the reversing effect of LY980503 (a benflumetol derivative) on multidrug resistance of MCF/Dox cell line and its mechanism.
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