如何逆转多药耐药成为提高化疗疗效的亟待解决的问题。
How to reverse MDR and improve the effectiveness of chemotherapy are important problems to be solved urgently.
蛋白酶体抑制剂可选择性地促进肿瘤细胞凋亡，逆转多药耐药。
Proteasome inhibitors can selectively promote the apoptosis of tumor cells and overcome MDR.
中药资源丰富，作用靶点多，可针对多药耐药机制复杂的特点，现有研究亦提示开发中药肿瘤多药耐药逆转剂有较好的前景。
And many researchers pay attention to natural drugs. Traditional Chinese medicine has plentiful resource and multitarget, and it can aim directly to the complicated mechanisms of MDR.
目的研究川芎嗪脂质体在体外对肿瘤细胞的细胞毒作用和对多药耐药的逆转作用，并研究脂质体剂型对上述作用的影响。
Objective: to study the cytotoxic effect of ligustrazine liposomes on tumor cell in vitro and the reversing effect on the MDR, and explore the influence of dosage form on the above effects.
为了解决这一问题，寻找作用强且毒副作用小的多药耐药逆转剂，成为抗癌药物研究的一个重要方向。
To resolve the question, as one of important studying ways, low toxic and effective reverse agent of MDR was tried to research.
目的：探讨消化道肿瘤的多药耐药机制和逆转策略。
Aims: To study the multi-drug resistance mechanism of digestive tract tumors and its reverse strategy.
目的寻找有效的多药耐药联合逆转剂。
Objective to develop effective combination of drug resistance modulators.
目的：研究粉防己碱与长春新碱合用能否逆转人乳腺癌M CF 7多药耐药细胞的抗凋亡作用。
Objective: to study whether the anti-apoptotic action is reversed by tetrandrine in a combination with vincristine in human breast carcinoma MCF-7 multidrug-resistant cells.
目的：证实抗P糖蛋白单克隆抗体（JSB1 ）能逆转人肾癌的天然多药耐药（MDR）性。
Purpose:To illustrate anti P gp monoclonal antibody(JSB 1) can reverse multidrug resistance(MDR) of the human kidney cancer.
结论雄黄可以逆转MCF7/ADM细胞的多药耐药性，并呈剂量依赖性；
Realgar can down regulate the expression of mdrl. mrp and bcrp in MCF 7/ADM cells.
目的探讨金克-槐耳颗粒是否能逆转人乳腺癌MCF-7/A细胞对阿霉素（ADM）的多药耐药性（MDR）及其逆转机制。
Objective The aim of this study is to discuss whether the Jinke plaster can reverse the MDR of the breast cancer cell strian MCF-7/A to ADM or not and the mechanism.
文章重点综述目前研究较多的多药耐药机制，并对肿瘤耐药逆转进展作简要介绍。
This paper provides a review on the hotspots of current MDR research. Moreover, the recent progress in the field of MDR reversal is also briefly introduced.
结论5 F 11 -DXR对敏感靶细胞的杀伤作用较d XR明显增强，并可有效逆转耐药靶细胞对DXR的多药耐药性。
Conclusion 5f11-dxr can remarkably increase the cytotoxicity of DXR to the sensitive target cells and even effectively reverse the drug-resistant cell lines to DXR.
逆转肿瘤细胞多药耐药旨在全部或部分恢复肿瘤细胞对化疗药物的敏感性，已成为肿瘤mdr研究的热点。
The aim of reversing MDR of gastric cancer cells is to entirely or partly recovery their chemotherapy to drugs, which has become a hot spot in solid tumor MDR research nowadays.
以下综述了中药提取物、中药单体及中药复方在逆转乳腺癌多药耐药方面的研究进展。
The effect of some herbs had been identified in vitro. This article mainly reviewed the research progress in reversing multidrug resistance to breast cancer with Chinese herb.
目的探讨本芴醇衍生物LY980 5 0 3对肿瘤多药耐药的逆转作用及其作用机理。
AIM To investigate the reversing effect of LY980503 (a benflumetol derivative) on multidrug resistance of MCF/Dox cell line and its mechanism.
本文对近年来多药耐药逆转剂的研究概况做了简要阐述。
The recent progress of multidrug resistance reversal agents are summarized in this brief review.
目的：制备MRK - 16修饰免疫脂质体，并检测免疫脂质体对非小细胞肺癌多药耐药细胞的杀伤及多药耐药逆转作用。
Objective: To determine the reversion of MDR of human lung carcinoma by ADM liposomes and ADM immunoliposomes modified by MRK-16 in vitro.
目的：研究卡维地洛对人膀胱癌耐药细胞株BIU-87/ADM的多药耐药性逆转作用。
Purpose:To study the reversal effects on multidrug resistance in multidrug-resistent bladder cell lines BIU-87/ADM.
结论FFJZ可能成为治疗白血病多药耐药安全有效的逆转药物。
Conclusion FFJZ may become a safe and effective multidrug resistance-reversing agent with low toxicity in leukemia chemotherapy.
结论FFJZ可能成为治疗白血病多药耐药安全有效的逆转药物。
Conclusion FFJZ may become a safe and effective multidrug resistance-reversing agent with low toxicity in leukemia chemotherapy.
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