研究不同偶联方法制备的力达霉素（LDM）与抗IV型胶原酶单抗3G11免疫偶联物的选择性抗肿瘤作用。
This study is to investigate the antitumor activities of the immunoconjugates composed of anti-type IV collagenase monoclonal antibody 3G11 and lidamycin (LDM) prepared by different methods.
如今，达托霉素在商业上获得了巨大成功。
EliLilly的研究人员发现达托霉素可以导致肌肉损伤并决定放弃这一药品。
The company’s researchers found that the drug caused muscle damage and recommended dropping it.
红霉素碱经肟化、保护再经甲基化、脱保护得到克拉霉素，总收率达40 %以上。
Clarithromycin was prepared from erythromycin a through oximation, protection, methylation and deprotection. The overall yield of clarithromycin was 40%.
结果在测定的4种大环内酯类药物中，淋球菌对阿奇霉素敏感性最高，达100 %；其次为罗红霉素，为96。04 %。
Results of all these 4 macrolides, the higher susceptibilities to gonococci were azithromycin and roxithromycin, in turn, the percentages of susceptibility were 100 %, 96. 04 %, respectively.
使肌吐高渗多胨琼脂培基的分离率达53～73％，而对照的庆大霉素琼脂培养基仅13％。
The isolating rate of this so called Hypertonic Carnosine Tween Medium (HCTM)was 53~73%, while the control-gentamicin medium was only 13%.
耐药性最强的是青霉素，耐药率达100%。
The antibiotics having strongest drug resistance was penicillin, up to 100%.
肌注后30 ~60分钟妥布霉素平均血药浓度达最高值。
Mean peek serum concentrations of tobramycin occur between 30 and about 60 minutes after intramuscular administration.
感染的肠球菌对万古霉素耐药的病人病死率最高，达92 % ，明显高于万古霉素敏感肠球菌肺感染的病死率（ 2 6% ） （P <0 0 5 ）。
The mortality of the patients infected by vancomycin-resistant enterococci was the highest (92%) and was higher than that of patients infected by vancomycin-sensitive enterococci (26%) ( P <0.05).
耐药性最强的是灰黄霉素，耐药率达86.6%，其次为氟康唑、伊曲康唑，耐药率分别是19.2%、10.6%。
The strongest drug resistance was griseofulvin, which reached up to 86.6%, followed by fluconazole (19.2%) and itraconazole (10.6 %).
本发明涉及一种达托霉素的合成方法。主要解决现有以玫孢链霉菌作为原料 合成成本过高的技术问题。
The invention relates to a daptomycin synthesis method for resolving the technical problem of prior art which uses rose spore streptomycete as raw material to cost high synthesis cost.
在红霉素耐药金黄色葡萄球菌和凝固酶阴性葡萄球菌中，克林霉素诱导型耐药的检出率分别达38.5%和25.0%。
The rate of inducible resistance to clindamycin was 38.5% and 25.0% in erythromycin-resistant isolates of S. aureus and coagulase-negative Staphylococcus respectively.
于是出现了治疗感染性心内膜炎的新药——达托霉素。
A new drug was found, daptomycin, to treat infective endocarditis.
果 ：复方克林霉素搽剂治疗寻常痤疮 ，wk总显效率达8.0 % ，对脓疱和丘疹的总有效率分别为9。%和 80 .7% ，不良反应率为.9%。
RESULTS: The total excellent response rate was 8 . 0%. The total effect rate on pustule and papule was 9. % and 80.7% respectively. The adverse reaction rate was . 9%.
果 ：复方克林霉素搽剂治疗寻常痤疮 ，wk总显效率达8.0 % ，对脓疱和丘疹的总有效率分别为9。%和 80 .7% ，不良反应率为.9%。
RESULTS: The total excellent response rate was 8 . 0%. The total effect rate on pustule and papule was 9. % and 80.7% respectively. The adverse reaction rate was . 9%.
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