目的探讨重组杆状病毒作为哺乳动物基因转导载体的可行性及其转导特点。
Objective to study the feasibility and the characteristics of recombinant baculovirus as mammalian gene transfer vector.
目的探讨稳定、高效、低毒的基因转导载体系统在基础研究和临床应用中的重要意义。
Objective to investigate the stable, high effective and low toxicity gene transfer vectors' basics in research and clinical application.
方法采用文献回顾的方法并结合当前实验研究，对肝细胞基因转导载体系统的研究和应用进展加以综述。
Methods Current status of hepatocyte directed gene transfer vectors were reviewed by history document and contemporary experimental advances analysis.
目的：探讨慢病毒载体在白血病细胞中的基因转导效率，为白血病基因治疗提供关键依据。
Objective to investigate the gene transduction efficiency of lentiviral vector in leukemia cells to provide key basis for leukemia gene therapy.
目的：探讨慢病毒载体在白血病细胞中的基因转导效率，为白血病基因治疗提供关键依据。
Abstract: Objective to investigate the gene transduction efficiency of lentiviral vector in leukemia cells to provide key basis for leukemia gene therapy.
结果表明：在双基因逆转录病毒载体介导的小鼠骨髓细胞的基因转导中，IRES与内部SV40启动子相比，更能保证双基因的共同表达。
Results showed that IRES was superior to SV40 promoter for guarantee of genes co expression in bicistronic retrovirus mediated gene therapy.
结论：基于慢病毒载体基因转导的高效性，该载体系统可作为白血病细胞基因转导的极好工具。
Conclusion This lentiviral vector is an excellent gene transduction system for leukemia cells because of its high gene transduction efficiency.
结论：基于慢病毒载体基因转导的高效性，该载体系统可作为白血病细胞基因转导的极好工具。
Conclusion This lentiviral vector is an excellent gene transduction system for leukemia cells because of its high gene transduction efficiency.
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