转基因动物的方法为研究基因的功能提供了一个理想的途径。
Transgenic animal is an ideal method to study the function of specific gene.
简述近年来重组受体、转基因动物、基因探针等基因工程技术在药物筛选中的应用。
The recent application of recombinant receptors, transgenic animals, genetic probe and other genetic engineering technology in drugs screening is introduced briefly.
但是传统的转基因动物技术大多操作复杂、成本高、效率低，从而限制了转基因技术的广泛应用。
However, most of the traditional techniques for producing transgenic animal were quite complicate, high cost and little effective, which limits their extensive application.
结果提示，选育双重杂合子转基因后代小鼠，是一条提高转基因动物外源基因表达水平的有效途径。
These results indicated that the selection of double heterozygotes among offspring may be a useful way to improve the expression of exogenous genes in the transgenic animals.
转基因动物技术已广泛渗透于分子生物学、免疫学、生物制药、畜牧育种以及器官移植等研究领域中。
Transgenic animal has been extended to various areas such as molecular biology, immunology, manufacture of pharmaceuticals and medicines, prologue breeding and organ transplantation.
广义的人工生命包括转基因动物和克隆动物，因此动物转基因技术和动物的克隆技术是人工生命的技术基础。
Because generalized artificial life includes transgenic animals and clone animals, transgenic and clone techniques are the technical basic of generalized artificial life.
用于细胞基因调控研究的RNA干涉技术和基因诱导表达方法，现在移植到了转基因动物中，并获得了理想结果。
RNA interference methods and gene inducible expression techniques to use on study of gene regulations in cells are transferred to making transgenic animals, and the ideal research results are gained.
转基因是近年来在生命科学领域广泛应用的新兴技术，目前80%以上的转基因动物模型是利用显微注射法构建完成的。
Gene transfer is a new and widely used technology in bioscience field. At present over 80 percent of transgenic animal models are constructed by means of microinjection.
基因在受体动物的基因组中随机整合，严重制约了转基因动物外源基因的稳定遗传，是转基因动物研究亟待解决的问题。
The random integration in receptor genome has restricted heredity stabilization of target gene in transgenic animals. It's the key problem which should be solved in the study of transgenic animals.
近年来，随着转基因动物制备技术的日趋成熟与完善，建立转基因动物模型已经成为研究真核基因表达调控的一种重要手段。
Recently, with the development of transgenic technology, producing transgenic animal model has become an important way to study the expression regulation of eukaryotic genes.
结论证实了转基因动物导入外源性基因整合位点是随机的；整合位点引起的肿瘤可以随着细胞发育的不同阶段，逐渐的显现。
It is proved that the conformity site of exogenous gene in APP transgenic mice is random, the tumor induced by gene conformity site could manifest with different stage of cell growing.
由于生产转基因动物的基本方法如原核注射法等普遍存在外源基因整合的低效性和随机性等问题，因而在应用中受到很大制约。
The basic reliable methods available to produce transgenic animal such as pronuclear microinjection has limited application by low efficiency and mosaic integration into the genome.
目的建立系统表达肝素结合性表皮生长因子的转基因动物模型，利用转基因动物模型研究HB - EGF与组织纤维化的关系。
Objective to construct heparin-binding epidermal growth factor-like growth factor transgenic mice in order to investigate the role of HB-EGF in the fibrosis of tissues.
用体细胞核移植技术生产转基因动物是目前一种最新、最有效的生产转基因动物的方法，而转基因体细胞系的建立是用这一方法生产转基因动物的基础。
Somatic cells nuclear transfer offers an efficient and practical method of producing transgenic animals, and the establishment of transgenic somatic cell lines are the basic of this method.
用体细胞核移植技术生产转基因动物是目前一种最新、最有效的生产转基因动物的方法，而转基因体细胞系的建立是用这一方法生产转基因动物的基础。
Somatic cells nuclear transfer offers an efficient and practical method of producing transgenic animals, and the establishment of transgenic somatic cell lines are the basic of this method.
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