ROS本身就是一个重要的致癌物质，它可引起基因突变和染色体修饰，诱导癌变。
Because the ROS can result in gene mutation and chromosome modification, it is the important carcinogen.
UVB辐射可诱导机体产生活性氧自由基，从而引起细胞生物学改变，导致基因突变、致癌和细胞死亡。
UVB irradiation can induce the formation of reactive oxygen species (ROS), and induce the change of cell biology, gene mutation, carcinogenesis and cell death.
为了研究Lrp5如何影响骨特性，我们建立了骨细胞特异性表达诱导型Lrp5基因突变的小鼠，该基因突变可导致人类高和低骨量表型。
To understand how Lrp5 influences bone properties, we generated mice with osteocyte-specific expression of inducible Lrp5 mutations that cause high and low bone mass phenotypes in humans.
为了研究Lrp5如何影响骨特性，我们建立了骨细胞特异性表达诱导型Lrp5基因突变的小鼠，该基因突变可导致人类高和低骨量表型。
To understand how Lrp5 influences bone properties, we generated mice with osteocyte-specific expression of inducible Lrp5 mutations that cause high and low bone mass phenotypes in humans.
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