结论:朊蛋白106- 126肽段能够诱导分化后的PC 12细胞凋亡,具有明确的毒性作用。
Conclusion Prion protein 106-126 peptide can induce apoptosis in differentiated PC12 cells and present cellular toxicity definitely.
结论:普乐林具有诱导HL - 60细胞分化及凋亡的双重作用。
Conclusion PR exerts effect on differentiation and induces apoptosis in HL-60 cells.
结论:HMBA对HL60细胞的作用主要是促进分化,诱导凋亡不是主要作用机制;
Conclusion: Inducing differentiation is the primary effect of HMBA on HL60 cells, and inducing apoptosis is not.
目的:研究蛞蝓粗提物对体外培养的人肺癌细胞H 14的抑制,以及诱导其分化、凋亡的作用。
Objective: to study the inhibitive effect of Limax extract on H14 and inducement effect of apoptosis and differentiation of H14 cells in vitro.
结论:ATRA并不能诱导HL-60细胞完成终端分化,但是该药可以诱导白血病细胞向成熟方向分化,而且已分化的肿瘤细胞于发生凋亡。
CONCLUSION: ATRA cannot induce HL 60 to achieve terminal differentiation, but the differentiation of HL 60 can be induced by ATRA and the differentiated leukemia cells are easy to apoptosis.
结论:APS有可能成为既能促进正常造血,又能抑制白血病等肿瘤细胞增殖,并诱导其凋亡或分化的天然诱导剂。
Conclusion: APS may not only promote normal hematopoiesis, but also inhibit the proliferation of leukemia cell and it can be a natural inducer for therapy of malignant tumor.
结论:JWA基因在实现ATRA及TPA诱导白血病细胞分化和凋亡中可能具有双重调节作用;
It is concluded that JWA may play double important roles in regulating ATRA and TPA-induced differentiation and apoptosis in leukemic cells.
近年来,出现了诱导分化和凋亡等治疗手段,且在某些肿瘤的治疗上已取得了可喜的效果。
Recently, leading differentiation and apoptosis were found, and of a few clinical practice had proved their effect.
目的:临床试验中对组蛋白脱乙酰基酶阻滞剂(HDACi)的研究目的在于诱导细胞分化,生长停止,和肿瘤细胞的凋亡。
Purpose: Histone deacetylase inhibitors (HDACi) are being studied in clinical trials with the aim to induce cellular differentiation, growth arrest, and apoptosis of tumor cells.
结论苯丁酸钠可明显抑制C6细胞增殖,诱导细胞分化,甚至诱发细胞凋亡。
Conclusions SPB can apparently inhibit the proliferation of C6 cells and can induce cell differentiation and even apoptosis of C6 cells.
结论:蟾蜍灵抑制nb 4细胞活力及诱导细胞发生凋亡,蟾蜍灵与atra联合应用可显著增强A TRA对NB 4细胞的诱导分化作用。
Conclusion the combination of ATRA with bufalin can significantly enhance the differentiation of NB4 cells in vitro culture by ATRA.
方法:分别用NBT还原力分析、DNA电泳分析观察药物诱导分化和凋亡作用;
METHODS: NBT dye reduction ability was used as the biomarker of differentiation of NB4 cells. Apoptosis was assayed through genomic DNA gel electrophoresis.
吡格列酮还能显著减轻PAN诱导的足细胞凋亡和坏死,而恢复足细胞的分化功能。
Further, pioglitazone significantly decreased PAN-induced podocyte apoptosis and necrosis while restoring podocyte differentiation.
吡格列酮还能显著减轻PAN诱导的足细胞凋亡和坏死,而恢复足细胞的分化功能。
Further, pioglitazone significantly decreased PAN-induced podocyte apoptosis and necrosis while restoring podocyte differentiation.
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